Reactome | Cxcr4 [plasma membrane]

Cxcr4 [plasma membrane]

Stable Identifier

R-RNO-2980772

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

CXCR4, O08565

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR downstream signalling (Rattus norvegicus)
    - G alpha (i) signalling events (Rattus norvegicus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7 [plasma membrane] (Rattus norvegicus)
        
        Cxcr4 [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7 [plasma membrane] (Rattus norvegicus)
        
        Cxcr4 [plasma membrane] (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Peptide ligand-binding receptors (Rattus norvegicus)
        
        Chemokine receptors bind chemokines (Rattus norvegicus)
        
        Receptors CXCR4 and 7 bind CXCL12 ligand (Rattus norvegicus)
        
        CXCR4,7 [plasma membrane] (Rattus norvegicus)
        
        Cxcr4 [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7:CXCL12 [plasma membrane] (Rattus norvegicus)
        
        CXCR4,7 [plasma membrane] (Rattus norvegicus)
        
        Cxcr4 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O08565

Gene Names

Cxcr4

Reference Genes

BioGPS Gene:60628 Cxcr4

ENSEMBL:ENSRNOG00000003866

ENSEMBL:ENSRNOG00000003866.8 Cxcr4

ENSEMBL:ENSRNOG00055020692

ENSEMBL:ENSRNOG00060018809

ENSEMBL:ENSRNOG00065009543

KEGG Gene (Rattus norvegicus):60628 Cxcr4

Monarch:60628 Cxcr4

NCBI Gene:60628 Cxcr4

UCSC:O08565 Cxcr4

Reference Transcript

RefSeq:NM_022205.3 Cxcr4

Other Identifiers

10767373

1370097_a_at

1373661_a_at

1389244_x_at

17683912

5651978

5843679

6024504

6043416

60628

6429291

6603165

A_43_P12159

A_44_P425580

GE1191707

GO:0001666

GO:0003779

GO:0004930

GO:0004950

GO:0005764

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005886

GO:0006935

GO:0007155

GO:0007186

GO:0008092

GO:0009986

GO:0016020

GO:0019722

GO:0019955

GO:0019957

GO:0023052

GO:0030155

GO:0030335

GO:0031252

GO:0031410

GO:0031625

GO:0032027

GO:0032991

GO:0038147

GO:0038160

GO:0043130

GO:0043226

GO:0048856

GO:0048870

GO:0050920

GO:0060089

GO:0071345

GO:1904018

GO:2000448

ILMN_1649910

PH_rn_0011399

U90610_at

U90610_g_at

rc_AA945737_at

Participates

as a component of

CXCR4:CXCL12 [plasma membrane] (Rattus norvegicus)

as a member of

CXCR4,7 [plasma membrane] (Rattus norvegicus)

Inferred From

CXCR4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_071541.2

ZINC - World Drugs

CXCR4_RAT

ZINC - FDA approved

CXCR4_RAT

ZINC - Substances

CXCR4_RAT

ZINC target

O08565

Ensembl

ENSRNOG00000003866, ENSRNOP00000005143, ENSRNOT00000005143

PRO

O08565

RGD

620465

ZINC - Predictions - Purchasable

CXCR4_RAT