Reactome | Pik3r1 [cytosol]

Pik3r1 [cytosol]

Stable Identifier

R-RNO-3080572

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

K63polyUb-PIK3R1, Q63787

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Regulation of signaling by CBL (Rattus norvegicus)
        
        CBL ubiquitinates PI3K (Rattus norvegicus)
        
        FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K alpha [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Rattus norvegicus)
        
        Pik3r1 [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K beta [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Rattus norvegicus)
        
        Pik3r1 [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K delta [cytosol] (Rattus norvegicus)
        
        K63polyUb-PI3K-regulatory subunits [cytosol] (Rattus norvegicus)
        
        Pik3r1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q63787 Pik3r1

Gene Names

Pik3r1

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:25513 Pik3r1

KEGG Gene (Rattus norvegicus):25513 Pik3r1

Monarch:25513 Pik3r1

NCBI Gene:25513 Pik3r1

UCSC:Q63787 Pik3r1

Reference Transcript

RefSeq:NM_013005.1 Pik3r1

Participates

as a member of

K63polyUb-PI3K-regulatory subunits [cytosol] (Rattus norvegicus)

Other forms of this molecule

Pi3k-p85 [cytosol]

Pik3r1 [cytosol]

Pik3r1 [plasma membrane]

Inferred From

K63polyUb-PIK3R1 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_037137.1

PRO

Q63787

RGD

3329

PDB

1FU5, 1FU6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62813 Gabra1	2	Gabra1 [plasma membrane] (R-RNO-8856427) Gabra1 [plasma membrane] (R-RNO-975262)	0.591	4
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) p-Y-Irs1 [cytosol] (R-RNO-112362) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.589	2
UniProt:P18545 PDE6G	2	PDE6G [photoreceptor disc membrane] (R-HSA-52449) PDE6G [plasma membrane] (R-HSA-4085973)	0.527	2

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