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Shootin-1 links L1 and retrograde actin flow

Stable Identifier
R-RNO-373735
Type
Reaction
Species
Rattus norvegicus
Compartment
Summation

Shootin-1 acts as a linker protein, binding L1 to moving actin filaments in axonal growth cones. This interaction mediates the migration of L1 on the plasma membrane from P-domain to the C-domain of the growth cone and enhances neurite elongation.

Literature References
PubMed ID Title Journal Year
18519736 Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth J Cell Biol 2008
Participants
Orthologous Events