Shootin-1 links L1 and retrograde actin flow

Stable Identifier
R-RNO-373735
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shootin-1 links L1 and retrograde actin flow
Shootin-1 acts as a linker protein, binding L1 to moving actin filaments in axonal growth cones. This interaction mediates the migration of L1 on the plasma membrane from P-domain to the C-domain of the growth cone and enhances neurite elongation.
Literature References
PubMed ID Title Journal Year
18519736 Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth

Shimada, T, Uemura, K, Toriyama, M, Inagaki, N, Sugiura, T, Kamiguchi, H, Watanabe, N

J Cell Biol 2008
Participants
Input
Output
Orthologous Events
Shootin-1 links L1 and retrograde actin flow (Homo sapiens)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2008-07-16)
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