Shootin-1 links L1 and retrograde actin flow

Stable Identifier
R-RNO-373735
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Shootin-1 links L1 and retrograde actin flow

Shootin-1 acts as a linker protein, binding L1 to moving actin filaments in axonal growth cones. This interaction mediates the migration of L1 on the plasma membrane from P-domain to the C-domain of the growth cone and enhances neurite elongation.

Literature References
PubMed ID Title Journal Year
18519736 Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth

Shimada, T, Toriyama, M, Uemura, K, Kamiguchi, H, Sugiura, T, Watanabe, N, Inagaki, N

J Cell Biol 2008
Participants
Orthologous Events
Authored
Reviewed
Created