Reactome | Cdca8 [cytosol]

Cdca8 [cytosol]

Stable Identifier

R-RNO-375288

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

CDCA8, Q6AXW0

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        Chromosome passenger complex [cytosol] (Rattus norvegicus)
        
        Cdca8 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q6AXW0

Gene Names

Cdca8

Reference Genes

BioGPS Gene:500545 Cdca8

ENSEMBL:ENSRNOG00000031431

ENSEMBL:ENSRNOG00000031431.6 Cdca8

ENSEMBL:ENSRNOG00055012622

ENSEMBL:ENSRNOG00060017142

ENSEMBL:ENSRNOG00065017769

KEGG Gene (Rattus norvegicus):500545 Cdca8

Monarch:500545 Cdca8

NCBI Gene:500545 Cdca8

UCSC:Q6AXW0 Cdca8

Reference Transcript

Other Identifiers

10879704

1371928_at

17810466

500545

5707790

5718776

6003355

6037499

6091637

6161324

6256130

6324307

6334761

6471582

6478904

6506895

6694668

A_44_P594610

GE15519

GO:0000278

GO:0000775

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005856

GO:0007059

GO:0007080

GO:0010369

GO:0015630

GO:0030496

GO:0032133

GO:0032991

GO:0043226

GO:0045171

GO:0051276

GO:0140014

ILMN_1370283

PH_rn_0005125

rc_AI230215_at

Participates

as a component of

Chromosome passenger complex [cytosol] (Rattus norvegicus)

Other forms of this molecule

Cdca8 [cytosol]

Cdca8 [nucleoplasm]

Inferred From

CDCA8 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020221.1, XP_008762286.1

Ensembl

ENSRNOG00000031431, ENSRNOT00000048293, ENSRNOP00000043633

PRO

Q6AXW0

RGD

1566306

Cite Us!