Reactome | Cenph [cytosol]

Cenph [cytosol]

Stable Identifier

R-RNO-375294

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

CENPH, F1M389

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate Formins (Rattus norvegicus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        CCAN network [cytosol] (Rattus norvegicus)
        
        CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)
        
        Cenph [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F1M389

Gene Names

Cenph

Reference Genes

ENSEMBL:ENSRNOG00000018615

ENSEMBL:ENSRNOG00000018615.9 Cenph

KEGG Gene (Rattus norvegicus):681185 Cenph

Reference Transcript

RefSeq:XM_008760701.1 Cenph

Other Identifiers

10821008

17744878

5673435

5741213

5756866

6041699

6213525

6277931

6311746

6344791

6400321

6443733

6536016

6623917

6640649

6652306

6701028

681185

A_64_P163219

GE1276129

GO:0000776

GO:0000939

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0043226

GO:0043515

GO:0051382

GO:0065003

PH_rn_0016330

PH_rn_0022476

Participates

as a component of

CENP-(H,I, K) complex [cytosol] (Rattus norvegicus)

Other forms of this molecule

Cenph [nucleoplasm]

Inferred From

CENPH [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_008758923.1

Ensembl

ENSRNOT00000025129, ENSRNOG00000018615, ENSRNOP00000025129

RGD

1583506

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