Reactome | Dsn1 [cytosol]

Dsn1 [cytosol]

Stable Identifier

R-RNO-375308

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

DSN1, A0A8I6ADJ6

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases Activate Formins (Rattus norvegicus)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        KMN network [cytosol] (Rattus norvegicus)
        
        Mis12 complex [cytosol] (Rattus norvegicus)
        
        Dsn1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6ADJ6

Gene Names

Dsn1

Reference Genes

ENSEMBL:ENSRNOG00000006236

ENSEMBL:ENSRNOG00000006236.8 Dsn1

Other Identifiers

10851251

1383323_at

1392131_at

17778813

499933

5661146

5735493

5739543

5764066

5819560

5866290

5892083

5909284

6009803

6012139

6025484

6116429

6223405

6347702

6358616

6410581

6498939

6502129

6548841

6696814

A_44_P461857

A_44_P461863

A_44_P945669

GE1210851

GE1238371

GO:0000444

GO:0000776

GO:0001650

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0007059

GO:0016604

GO:0043226

GO:0051301

PH_rn_0006862

rc_AI175721_at

Participates

as a component of

Mis12 complex [cytosol] (Rattus norvegicus)

Other forms of this molecule

Dsn1 [extracellular region]

Dsn1 [azurophil granule lumen]

Inferred From

DSN1 [cytosol] (Homo sapiens)

Cross References

Ensembl

ENSRNOG00000006236, ENSRNOP00000091357, ENSRNOT00000109507

RGD

1565179

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