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Vhl [cytosol]
Stable Identifier
R-RNO-391423
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
VHL, Q64259
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Proteasome proteolyzes ub-HIF-alpha (Rattus norvegicus)
VBC complex (with or without LIMD1) [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Rattus norvegicus)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
RBX1-CUL2-EloB,C-VHL [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
26S proteasome degrades HIFalpha (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
VBC complex [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
RHOBTB3 ATPase cycle (Rattus norvegicus)
RHOBTB3 binds interacting proteins at trans-Golgi network (Rattus norvegicus)
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
RHOBTB3:ATP:RHOBTB3 interacting proteins [trans-Golgi network membrane] (Rattus norvegicus)
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
Vhl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q64259
Gene Names
Vhl
Reference Genes
BioGPS Gene:24874 Vhl
ENSEMBL:ENSRNOG00000010258
ENSEMBL:ENSRNOG00000010258.4 Vhl
ENSEMBL:ENSRNOG00055009089
ENSEMBL:ENSRNOG00060013774
ENSEMBL:ENSRNOG00065028191
KEGG Gene (Rattus norvegicus):24874 Vhl
Monarch:24874 Vhl
NCBI Gene:24874 Vhl
UCSC:Q64259 Vhl
Reference Transcript
RefSeq:NM_052801.1 Vhl
Other Identifiers
10857887
1368076_at
17786163
24874
5925141
5947369
5967964
6223944
6228116
6228879
6337804
6512455
A_44_P1017315
A_44_P477135
A_64_P005749
GE20865
GO:0001525
GO:0003309
GO:0003310
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005929
GO:0006582
GO:0010468
GO:0010498
GO:0010629
GO:0012501
GO:0014069
GO:0015031
GO:0023052
GO:0030154
GO:0030163
GO:0030198
GO:0031462
GO:0032880
GO:0034330
GO:0043226
GO:0043534
GO:0044877
GO:0045446
GO:0045602
GO:0048069
GO:0048593
GO:0048856
GO:0048870
GO:0048877
GO:0050679
GO:0061072
GO:0061073
GO:0070243
GO:0070244
GO:0097411
GO:0098978
GO:0099175
GO:0140252
GO:1902072
GO:2001233
ILMN_1367225
PH_rn_0006403
S80345_s_at
U14746_at
Participates
as a member of
RHOBTB3 interacting proteins [cytosol] (Rattus norvegicus)
CUL2-box protein [cytosol] (Rattus norvegicus)
as a component of
VBC complex [cytosol] (Rattus norvegicus)
Other forms of this molecule
Vhl [nucleoplasm]
Vhl [nucleoplasm]
Inferred From
VHL [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_434688.1
Ensembl
ENSRNOT00000013727
,
ENSRNOP00000013727
,
ENSRNOG00000010258
PRO
Q64259
RGD
3960
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