Reactome | FAAP24 [nucleoplasm]

FAAP24 [nucleoplasm]

Stable Identifier

R-RNO-419533

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

D3ZE71

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Fanconi Anemia Pathway (Rattus norvegicus)
  - ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - FA core complex assembles at DNA interstrand crosslinks (ICLs) (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - FANCM:FAAP24:APITD1:STRA13:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - FANCD2 deubiquitination by USP1:WDR48 (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex (Rattus norvegicus)
    - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - FANCM binds FAAP24 (Rattus norvegicus)
    - FAAP24 [nucleoplasm] (Rattus norvegicus)
    - FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
      - FAAP24 [nucleoplasm] (Rattus norvegicus)
  - Monoubiquitination of FANCD2:FANCI (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - p-FANCD2:p-FANCI:UBE2T:p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - p-FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - POLN binds ICL-DNA (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - The complex of ATR and ATRIP is recruited to ICL-DNA (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
      - FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] (Rattus norvegicus)
      - FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex:ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA Core Complex [nucleoplasm] (Rattus norvegicus)
        
        FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
  - Translesion synthesis across unhooked ICL by POLN (Rattus norvegicus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Rattus norvegicus)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Rattus norvegicus)
        
        FA core complex [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)
    - p-FA Core Complex [nucleoplasm] (Rattus norvegicus)
      - p-S1045-FANCM:FAAP24 [nucleoplasm] (Rattus norvegicus)
        
        FAAP24 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZE71

Reference Genes

BioGPS Gene:502320

dbSNP Gene:502320

ENSEMBL:ENSRNOG00000022393

KEGG Gene (Rattus norvegicus):502320

Monarch:502320

NCBI Gene:502320

UCSC:D3ZE71

Reference Transcript

Other Identifiers

10721094

1379319_at

1564719

17632056

502320

5849980

6033402

6060282

6078892

6147062

6273675

6466588

6681322

A_44_P133700

A_44_P576764

A_64_P030122

AABR07002993

CH473979

EDM07625

ENSRNOG00000022393

ENSRNOP00000031862

ENSRNOT00000033396

EntrezGene:502320

Faap24

Faap24-201

GE13792

GO:0003674

GO:0003682

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0006259

GO:0006950

GO:0008150

GO:0032991

GO:0034641

GO:0036297

GO:0043226

GO:0043231

GO:0043240

IPR010994

IPR026985

NM_001109335

NP_001102805

PF12826

PH_rn_0009936

rc_AA901179_at

rc_AI044740_at

UPI0000DA198A

XM_006228896

XP_006228958

Participant Of

hasComponent

input

FANCM binds FAAP24

Inferred From

FAAP24 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001102805.1, XP_006228958.1