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Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane]
Stable Identifier
R-RNO-421889
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
Gnai1, GNAI1_RAT, Gnai1
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Signal amplification (Rattus norvegicus)
ADP signalling through P2Y purinoceptor 12 (Rattus norvegicus)
Gi activation by P2Y purinoceptor 12 (Rattus norvegicus)
ADP:P2RY12:G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
ADP:P2RY12:G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Adrenaline,noradrenaline inhibits insulin secretion (Rattus norvegicus)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Rattus norvegicus)
G-alpha(i,o):GDP:G beta:G gamma [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GTP [plasma membrane] (Rattus norvegicus)
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Gi,Go Heterotrimeric G-protein complex dissociates (Rattus norvegicus)
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GTP [plasma membrane] (Rattus norvegicus)
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane] (Rattus norvegicus)
G-alpha(i,o):GTP [plasma membrane] (Rattus norvegicus)
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
GABA receptor activation (Rattus norvegicus)
GABA B receptor activation (Rattus norvegicus)
Activation of GABAB receptors (Rattus norvegicus)
Adenylate cyclase inhibitory pathway (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Active G alpha (i)–i1/i2/i3 binds RGS proteins (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha (i):GTP:RGS [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3 (Rattus norvegicus)
G alpha (i):GDP:RGS [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated (Rattus norvegicus)
G alpha (i):GDP:RGS [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha (i):GTP:RGS [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha (i):GTP:SRC-1 [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G protein alpha (i):GTP:p-Y419-SRC [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G protein alpha (i):GTP:p-Y419-SRC [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein mediated events (Rattus norvegicus)
Adenylate cyclase inhibitory pathway (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Dissociation of the Gi alpha:G olf complex (Rattus norvegicus)
(Gi alpha1:GDP:Adenylate cyclase):(G alpha-olf:GDP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex (Rattus norvegicus)
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
G-protein alpha (i):GTP:Adenylate cyclase [plasma membrane] (Rattus norvegicus)
G alpha (i): GTP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Membrane estrogen receptors bind SRC (Rattus norvegicus)
G-protein alpha (i):GDP [plasma membrane] (Rattus norvegicus)
G alpha (i) [plasma membrane] (Rattus norvegicus)
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P10824 Gnai1
Gene Names
Gnai1, Gnai-1
Chain
initiator methionine:, chain:2-354
Reference Genes
BioGPS Gene:25686 Gnai1
ENSEMBL:ENSRNOG00000057096.2 Gnai1
ENSEMBL:ENSRNOG00055021986 Gnai1
ENSEMBL:ENSRNOG00060012765 Gnai1
ENSEMBL:ENSRNOG00065016882 Gnai1
KEGG Gene (Rattus norvegicus):25686 Gnai1
Monarch:25686 Gnai1
NCBI Gene:25686 Gnai1
Reference Transcript
RefSeq:NM_013145.1 Gnai1
Other Identifiers
10853229
1372104_at
1387505_at
17780950
25686
5708624
5783696
5862392
5872105
6116183
6177326
6220091
6285401
6468652
A_43_P11734
GE12903
GE20207
GE21759
GO:0003824
GO:0003924
GO:0005525
GO:0007165
GO:0007186
GO:0007188
GO:0016787
GO:0019001
GO:0023052
GO:0031683
M17527_at
PH_rn_0011560
rc_AI228557_at
Participates
as a candidate of
G alpha (i,o) (candidates) [plasma membrane] (Rattus norvegicus)
as a component of
G alpha (i)1:GDP [plasma membrane] (Rattus norvegicus)
G alpha (i)1:GTP [plasma membrane] (Rattus norvegicus)
as a member of
G alpha (i) [plasma membrane] (Rattus norvegicus)
Inferred From
GNAI1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_037277.1
Ensembl
ENSRNOG00000057096
,
ENSRNOT00000091004
,
ENSRNOP00000074036
PRO
P10824
RGD
2713
PDB
1BOF
,
3FFA
,
1GFI
,
2ZJZ
,
1GDD
,
1CIP
,
1FQJ
,
1FQK
,
1BH2
,
1AS0
,
1SVK
,
1GG2
,
4N0D
,
6VMS
,
4PAN
,
6UKT
,
1AS2
,
3FFB
,
4PAM
,
7S0G
,
1SHZ
,
3AH8
,
6TYL
,
1GIL
,
4PAQ
,
5KDO
,
3V00
,
1GP2
,
1GIA
,
4PAO
,
4N0E
,
1AS3
,
2BCJ
,
5KDL
,
1SVS
,
7S0F
,
6M8H
,
3D7M
,
2RGN
,
1AGR
,
2ZJY
,
1GIT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62873 GNB1
5
GNB1 [photoreceptor disc membrane]
(R-HSA-55373)
Unfolded GNB1 [cytosol]
(R-HSA-6814200)
Partially folded GNB1 [cytosol]
(R-HSA-8850526)
GNB1 [plasma membrane]
(R-HSA-164347)
GNB1 [cytosol]
(R-HSA-6814412)
0.488
2
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