NO binds to Guanylate Cyclase

Stable Identifier
R-RNO-427279
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
NO binds to Guanylate Cyclase

Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.

Literature References
PubMed ID Title Journal Year
20623 Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations

Arnold, WP, Mittal, CK, Katsuki, S, Murad, F

Proc Natl Acad Sci U S A 1977
Participants
Orthologous Events
Authored
Reviewed
Created