Soluble guanylate cyclase converts GTP to cGMP

Stable Identifier
R-RNO-427288
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Soluble guanylate cyclase converts GTP to cGMP
Soluble guanylate cyclase (sGC) is a heterodimeric hemoprotein that selectively binds Nitric Oxide (NO). NO binding stimulates the synthesis of cGMP, which then binds to phosphodiesterases (PDE), ion-gated channels, and cGMP-dependent protein kinases (cGK) to regulate several physiological functions including vasodilation, platelet aggregation and neurotransmission.
Literature References
PubMed ID Title Journal Year
4982201 Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine trihosphate

SUTHERLAND, EW, Hardman, JG

J Biol Chem 1969
2827195 Cyclic GMP synthesis and function

Murad, F, Waldman, SA

Pharmacol Rev 1987
Participants
Catalyst Activity

guanylate cyclase activity of Guanylate cyclase, soluble [cytosol]

Orthologous Events
Authored
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