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Vav3 [cytosol]
Stable Identifier
R-RNO-430152
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
VAV3, A0A8I5ZPB5
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPH-ephrin mediated repulsion of cells (Rattus norvegicus)
SFKs phosphorylate VAV2,3 (Rattus norvegicus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-EPHs bind VAV2,3 (Rattus norvegicus)
EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
VAV1 is a GEF for Rho/Rac family GTPases (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
VAV family:PIP2 [plasma membrane] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-SLP-76 binds VAV (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-SLP-76:VAV [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Release of p-PLCG1 (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Autophosphorylation of BTK/ITK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Phosphorylation and activation of VAV (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Phosphorylation of VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRAGE signals death through JNK (Rattus norvegicus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (12/13) signalling events (Rattus norvegicus)
GEFs activate RhoA,B,C (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
Src kinases phosphorylate VAV (Rattus norvegicus)
PIP3:VAV1,2,3 [plasma membrane] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
CDC42 GTPase cycle (Rattus norvegicus)
CDC42 GEFs activate CDC42 (Rattus norvegicus)
CDC42 GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 GEFs activate RAC1 (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 GEFs activate RAC2 (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
RHOA GTPase cycle (Rattus norvegicus)
RHOA GEFs activate RHOA (Rattus norvegicus)
RHOA GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
RHOG GTPase cycle (Rattus norvegicus)
RHOG GEFs activate RHOG (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
Vav3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A8I5ZPB5
Gene Names
Vav3
Reference Genes
BioGPS Gene:295378 Vav3
ENSEMBL:ENSRNOG00000020485
ENSEMBL:ENSRNOG00000020485.7 Vav3
KEGG Gene (Rattus norvegicus):295378 Vav3
Monarch:295378 Vav3
NCBI Gene:295378 Vav3
Reference Transcript
RefSeq:NM_001191714.1 Vav3
Other Identifiers
10818454
1393605_at
17742029
295378
5647346
5667192
5670487
5768204
5848720
5851910
5854433
5891614
5891664
6050844
6113059
6140148
6172428
6180436
6198804
6211398
6252679
6284083
6362900
6405278
6425763
6446298
6488141
6516912
6524148
6528391
6537938
6541709
6546722
6627368
6690374
A_44_P747071
A_44_P873794
A_64_P133791
GE1236122
GO:0001772
GO:0002376
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005886
GO:0006906
GO:0006974
GO:0007155
GO:0007229
GO:0007264
GO:0009410
GO:0016192
GO:0016477
GO:0023052
GO:0030031
GO:0030032
GO:0030593
GO:0030890
GO:0035556
GO:0045785
GO:0048870
GO:0050853
GO:0051897
GO:0061024
GO:0098772
ILMN_1363934
PH_rn_0016449
PH_rn_0023041
Participates
as a member of
RHOA GEFs [cytosol] (Rattus norvegicus)
RAC2 GEFs [cytosol] (Rattus norvegicus)
RHOG GEFs [cytosol] (Rattus norvegicus)
VAV2,VAV3 [cytosol] (Rattus norvegicus)
GEFs [cytosol] (Rattus norvegicus)
VAV1,2,3 [cytosol] (Rattus norvegicus)
as a candidate of
CDC42 GEFs [cytosol] (Rattus norvegicus)
RAC1 GEFs [cytosol] (Rattus norvegicus)
VAV family [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Vav3 [cytosol]
Inferred From
VAV3 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001178643.1
Ensembl
ENSRNOP00000080097
,
ENSRNOT00000098387
,
ENSRNOG00000020485
RGD
1565941
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