Reactome | Arhgef7 [cytosol]

Arhgef7 [cytosol]

Stable Identifier

R-RNO-430346

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

ARHGEF7, O55043

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - Ephrin signaling (Rattus norvegicus)
        
        GIT1 binds bPIX (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAK binds RAC and bPIX (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAKs autophosphorylate (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        PAKs phosphorylate MLC (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        Arhgef7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:O55043 Arhgef7

Gene Names

Arhgef7, Pak3bp, Pixb

Chain

chain:1-646

Reference Genes

BioGPS Gene:114559 Arhgef7

KEGG:rno:114559 Arhgef7

Monarch:114559 Arhgef7

NCBI Gene:114559 Arhgef7

UCSC:O55043 Arhgef7

Reference Transcript

RefSeq:NM_001113522.1 Arhgef7

Participates

as a candidate of

as an input of

GIT1 binds bPIX (Rattus norvegicus)

as a component of

as a member of

GEFs [cytosol] (Rattus norvegicus)

Other forms of this molecule

p-S516-Arhgef7 [cytosol]

Arhgef7 [cytosol]

Inferred From

ARHGEF7 [cytosol] (Homo sapiens)

Cross References

PRO

O55043

RGD

620624

PDB

3L4F, 3QJN, 2W6B, 2G6F, 2DF6, 2AK5, 2P4R

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.655	8
UniProt:Q13191-1 CBLB			0.558	2
UniProt:P35465	4	PAK1 [plasma membrane] (R-RNO-3928409) phospho-p-S144,T423-PAK1 [plasma membrane] (R-RNO-3928472) PAK1 [cytosol] (R-RNO-162629) phospho-p-S144,T423-PAK1 [cytosol] (R-RNO-399819)	0.553	2
UniProt:P41227 NAA10			0.524	3