Znt2 facilitates zinc vesicular sequestration

Stable Identifier
R-RNO-437094
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
endosome membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Znt2 facilitates zinc vesicular sequestration
Rat Znt2 can confer resistance to zinc toxicity in a zinc-sensitive cell line. Znt2 mediated the accumulation of zinc in endosomes, visualized within these vesicles with zinquin, a zinc-specific fluorescent probe (Palmiter RD et al, 1996).
Literature References
PubMed ID Title Journal Year
8617223 ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration

Findley, SD, Cole, TB, Palmiter, RD

EMBO J 1996
Participants
Input
Output
Catalyst Activity

zinc ion transmembrane transporter activity of Znt2 [endosome membrane]

Physical Entity
Znt2 [endosome membrane] (Rattus norvegicus)
Activity
zinc ion transmembrane transporter activity (GO:0005385)
Orthologous Events
ZnT2 facilitates zinc vesicular sequestration (Homo sapiens)
Authored
Jassal, B  (2009-09-11)
Reviewed
He, L  (2009-11-12)
Created
Jassal, B  (2009-09-11)
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