PDK1 activates PKC zeta

Stable Identifier
R-RNO-437185
Type
Reaction
Species
Rattus norvegicus
Compartment
Summation

3-phosphoinositide dependent protein kinase-1 (PDK1, also known as PKB kinase because of its activity at Protein kinase B) phosphorylates T410 of Protein kinase C zeta type (PKC zeta), leading to activation. The motif surrounding T410 is highly conserved in other PKC family members suggesting that PDK1 might activate other PKCs.

Literature References
PubMed ID Title Journal Year
9768361 Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

Chou, MM, Hou, W, Johnson, J, Graham, LK, Lee, MH, Chen, CS, Newton, AC, Schaffhausen, BS, Toker, A

Curr Biol 1998
Participants
Catalyst Activity
Catalyst Activity
Title
3-phosphoinositide-dependent protein kinase activity of PIP3:PDK1:AKT:PKC zeta [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed