cAMP Induces dissociation of active protein kinase A subunits from the PKA:Akap150:Iqgap1 complex

Stable Identifier
R-RNO-446974
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
cAMP Induces dissociation of active protein kinase A subunits from the PKA:Akap150:Iqgap1 complex

The regulatory subunits of protein kinase A bind cAMP which causes the catalytic subunits of protein kinase A to dissociate and become active. The regulatory subunits remain tethered at the plasma membrane by interaction with Akap5/Akap150 and Iqgap1.

Literature References
PubMed ID Title Journal Year
12938160 Identification of an IQGAP1/AKAP79 complex in beta-cells

Nauert, JB, Rigas, JD, Lester, LB

J Cell Biochem 2003
11181538 Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation

Lester, LB, Faux, MC, Nauert, JB, Scott, JD

Endocrinology 2001
19073898 Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring

Faruque, OM, Le-Nguyen, D, Lajoix, AD, Vives, E, Petit, P, Bataille, D, Hani, el-H

Am J Physiol Cell Physiol 2009
9405718 Anchoring of protein kinase A facilitates hormone-mediated insulin secretion

Lester, LB, Langeberg, LK, Scott, JD

Proc Natl Acad Sci U S A 1997
Participants
Input
Output
Orthologous Events
PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP (Homo sapiens)
Authored
May, B  (2009-11-19)
Reviewed
May, B  (2009-11-19)
Created
May, B  (2009-11-19)