Reactome | MAP2K7 [cytosol]

MAP2K7 [cytosol]

Stable Identifier

R-RNO-450276

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q4KSH7

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-17 signaling (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - FCERI mediated MAPK activation (Rattus norvegicus)
      - Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
  - Toll-like Receptor Cascades (Rattus norvegicus)
    - Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
      - MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
      - MyD88-independent TLR4 cascade (Rattus norvegicus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
      - MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)
    - Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
      - MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
        
        MAP kinase activation (Rattus norvegicus)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
        
        MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)
        
        MAP2K7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q4KSH7

Reference Genes

BioGPS Gene:363855

ENSEMBL:ENSRNOG00000001047

ENSEMBL:ENSRNOG00000001047.7

ENSEMBL:ENSRNOG00055004114

ENSEMBL:ENSRNOG00060002502

ENSEMBL:ENSRNOG00065005808

KEGG Gene (Rattus norvegicus):363855

Monarch:363855

NCBI Gene:363855

UCSC:Q4KSH7

Reference Transcript

RefSeq:NM_001025425.1

Other Identifiers

10759531

10759538

1371825_at

1373109_at

17675044

17675050

17675053

363855

5664465

5677252

5691458

5813501

5840542

5857082

5862139

5870871

5933543

5935818

5942274

5986811

6013863

6054745

6079906

6104360

6129139

6130828

6141069

6152191

6156208

6170092

6170550

6197966

6230050

6232699

6239580

6283411

6285935

6328971

6331455

6334475

6337976

6360191

6413022

6432916

6480947

6515592

6523678

6599278

6656343

6715341

6721842

6723119

6737382

A_43_P18491

A_44_P231628

A_64_P155633

GE1127215

GE1206843

GE1213609

GE14496

GO:0003824

GO:0004672

GO:0005524

GO:0006468

GO:0016740

GO:0036211

GO:0140096

PH_rn_0002696

PH_rn_0003166

PH_rn_0015228

PH_rn_0019060

rc_AI102286_at

rc_AI177058_at

Participates

as an input of

Phosphorylation of MEK7 by MEKK1 (Rattus norvegicus)

as a member of

MAP2K7,MAP2K4 [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-p-S271,T275-MAP2K7 [cytosol]

Inferred From

MAP2K7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020596.1

Ensembl

ENSRNOG00000001047, ENSRNOT00000104881, ENSRNOP00000086269

PRO

Q4KSH7

RGD

1560043

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