Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-K63polyUb-hp-IRAK1 [cytosol]
Stable Identifier
R-RNO-451565
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
A0A0G2JYX9
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates IRAK1 (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-K63polyUb-hp-IRAK1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A0G2JYX9
Reference Genes
BioGPS Gene:363520
ENSEMBL:ENSRNOG00000060869
ENSEMBL:ENSRNOG00000060869.2
Monarch:363520
NCBI Gene:363520
Reference Transcript
RefSeq:XM_006229598.2
Other Identifiers
10940296
1373379_at
1394991_at
17879951
363520
5628739
5632056
5676323
5801606
5811142
5826030
5831432
5877501
5884977
5965069
5984965
6067909
6094720
6131089
6203680
6278092
6298705
6318316
6352563
6434505
6463199
6597037
A_44_P532352
GE18534
GO:0001959
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005829
GO:0006468
GO:0007155
GO:0007165
GO:0007249
GO:0009986
GO:0016301
GO:0016740
GO:0019901
GO:0023052
GO:0031663
GO:0032481
GO:0032496
GO:0032991
GO:0034134
GO:0036211
GO:0038172
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0046982
GO:0060337
GO:0070498
GO:0070555
GO:0098542
GO:0140096
GO:1904996
ILMN_1651046
PH_rn_0001813
rc_AA848895_at
rc_AI136692_at
Participates
as an input of
NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)
as a component of
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-K63polyUb-hp-IRAK1 [endosome membrane]
phospho-p-S376,T387-IRAK1 [cytosol]
phospho-p-S,T-IRAK1 [cytosol]
phospho-p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
phospho-p-2S,S376,T,T209,T387-IRAK1 [cytosol]
IRAK1 [cytosol]
Inferred From
K63polyUb-hp-IRAK1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376 (in Homo sapiens)
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134 (in Homo sapiens)
Coordinate
134
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160 (in Homo sapiens)
Coordinate
160
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_006229660.1
Ensembl
ENSRNOG00000060869
,
ENSRNOT00000092207
,
ENSRNOP00000070832
RGD
1563841
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text