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phospho-Irak1 [cytosol]
Stable Identifier
R-RNO-451565
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
K63polyUb-hp-IRAK1, B2RYH5
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
K63polyUb-IRAK1 dissociates (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
NEMO binds polyubiquitinated IRAK1 (Rattus norvegicus)
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates IRAK1 (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3):UBE2N:UBE2V1 [cytosol] (Rattus norvegicus)
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
IRAK1 recruits IKK complex (Rattus norvegicus)
NEMO subunit of IKK complex binds to activated IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol] (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
Pellino ubiquitinates hp-IRAK1 (Rattus norvegicus)
K63-linked polyUb p-IRAK1:TRAF6 [cytosol] (Rattus norvegicus)
phospho-Irak1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B2RYH5
Gene Names
Irak1
Reference Genes
BioGPS Gene:363520 Irak1
ENSEMBL:ENSRNOG00000060869
ENSEMBL:ENSRNOG00000060869 Irak1
KEGG Gene (Rattus norvegicus):363520 Irak1
Monarch:363520 Irak1
NCBI Gene:363520 Irak1
Reference Transcript
RefSeq:NM_001127555.1 Irak1
Other Identifiers
10940296
1373379_at
1394991_at
17879951
363520
5628739
5632056
5676323
5801606
5811142
5826030
5831432
5877501
5884977
5965069
5984965
6067909
6094720
6131089
6203680
6278092
6298705
6318316
6352563
6434505
6463199
6597037
A_44_P532352
GE18534
GO:0000166
GO:0001959
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0005149
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005811
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007155
GO:0007165
GO:0007250
GO:0007254
GO:0007568
GO:0008150
GO:0008283
GO:0009058
GO:0016020
GO:0016301
GO:0016310
GO:0019221
GO:0031072
GO:0031663
GO:0032088
GO:0032481
GO:0032494
GO:0032496
GO:0032991
GO:0034134
GO:0034142
GO:0034605
GO:0034641
GO:0035556
GO:0042802
GO:0042803
GO:0043123
GO:0043167
GO:0043226
GO:0043406
GO:0043507
GO:0045087
GO:0045892
GO:0046777
GO:0046982
GO:0048661
GO:0051092
GO:0060337
GO:0070498
GO:0070555
GO:0071222
GO:0071456
GO:0090370
GO:1901224
GO:1904996
ILMN_1651046
PH_rn_0001813
rc_AA848895_at
rc_AI136692_at
Participant Of
hasComponent
K63-linked polyUb p-IRAK1:TRAF6 [cytosol]
K63polyUb-hp-IRAK1:p-Pellino-1,2,(3) [cytosol]
Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol]
input
NEMO binds polyubiquitinated IRAK1
output
K63polyUb-IRAK1 dissociates
Other forms of this molecule
phospho-Irak1 [endosome membrane]
phospho-Irak1 [endosome membrane]
phospho-Irak1 [cytosol]
phospho-Irak1 [cytosol]
phospho-Irak1 [plasma membrane]
phospho-Irak1 [cytosol]
Irak1 [cytosol]
Inferred From
K63polyUb-hp-IRAK1 [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 209 (in Homo sapiens)
Coordinate
209
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 376 (in Homo sapiens)
Coordinate
376
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 387 (in Homo sapiens)
Coordinate
387
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at unknown position
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 134 (in Homo sapiens)
Coordinate
134
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63-polyubiquitin [cytosol]) at 160 (in Homo sapiens)
Coordinate
160
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001121027.1
Ensembl
ENSRNOT00000092207
,
ENSRNOG00000060869
,
ENSRNOP00000070832
RGD
1563841
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