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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
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Cytomics
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Citing us
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Analyse gene expression
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p110 beta [cytosol]
Stable Identifier
R-RNO-451713
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform, Pik3cb
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Tie2 Signaling (Rattus norvegicus)
Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85 bound to Tie2 [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, beta, gamma [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Recruitment of PI3K to plasma membrane (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL ubiquitinates PI3K (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
K63polyUb-PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K binds to p-6Y-SYK (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PIK3C(1) [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R2 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R3 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)
PIK3(2) [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R2 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R3 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS:GTP binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p21 RAS:GTP:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K bound to EPOR [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
Active ALK recruits PI3K (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by LTK (Rattus norvegicus)
Active LTK receptor binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
PI3-kinase binds to the active receptor (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
p-AXL binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
p110 beta [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9Z1L0 Pik3cb
Gene Names
Pik3cb
Chain
chain:1-1070
Reference Genes
BioGPS Gene:85243 Pik3cb
KEGG Gene (Rattus norvegicus):85243 Pik3cb
Monarch:85243 Pik3cb
NCBI Gene:85243 Pik3cb
UCSC:Q9Z1L0 Pik3cb
Reference Transcript
RefSeq:NM_053481.2 Pik3cb
Participates
as a component of
PI3K_RAT [cytosol] (Rattus norvegicus)
K63polyUb-PI3K beta [cytosol] (Rattus norvegicus)
Pi3k beta [cytosol] (Rattus norvegicus)
PI3K beta [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R2 [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R1 [cytosol] (Rattus norvegicus)
PIK3CB:PIK3R3 [cytosol] (Rattus norvegicus)
as a member of
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Inferred From
PIK3CB [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_445933.1
IntEnz
2.7.1.153
PRO
Q9Z1L0
RGD
620917
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