p85 associates with both p-Nephrin and CD2AP

Stable Identifier
R-RNO-451755
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p85 associates with both p-Nephrin and CD2AP
The regulatory p85 subunit of PI3K recognizes and binds to both phosphorylated nephrin and its binding partner, CD2AP. By mutation analysis, nephrin Y1158 was shown to be necessary for the interaction. This interaction allows the catalytic subunit p110 to act on phospholipids of the inner leaflet of the cell membrane. This leads to downstream phosphorylation and inactivation of the apoptotic factor Bad via the serine-threonine kinase AKT.
Literature References
PubMed ID Title Journal Year
12832477 Nephrin and CD2AP associate with phosphoinositide 3-OH kinase and stimulate AKT-dependent signaling

Huber, TB, Hartleben, B, Kim, J, Schmidts, M, Schermer, B, Keil, A, Egger, L, Lecha, RL, Borner, C, Pavenstädt, H, Shaw, AS, Walz, G, Benzing, T

Mol Cell Biol 2003
16630808 Nck links nephrin to actin in kidney podocytes

Tryggvason, K, Pikkarainen, T, Patrakka, J

Cell 2006
18274541 Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands

Schlondorff, J

Kidney Int 2008
Participants
Input
Output
Orthologous Events
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
Authored
de Bono, B  (2008-02-26)
Garapati, P V  (2008-02-26)
Reviewed
Huber, TB  (2010-05-20)
Grahammer, Florian  (2010-05-20)
Created
Garapati, P V  (2010-01-11)
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