Reactome | Mta2 [nucleoplasm]

Mta2 [nucleoplasm]

Stable Identifier

R-RNO-4657009

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

MTA2, F7F888

Locations in the PathwayBrowser

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Chromatin organization (Rattus norvegicus)

- Chromatin modifying enzymes (Rattus norvegicus)
  - HDACs deacetylate histones (Rattus norvegicus)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Rattus norvegicus)
      - HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        HDAC1:2-containing complex [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase I Transcription (Rattus norvegicus)
  - RNA Polymerase I Promoter Clearance (Rattus norvegicus)
    - RNA Polymerase I Transcription Initiation (Rattus norvegicus)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Rattus norvegicus)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)
- RNA Polymerase II Transcription (Rattus norvegicus)
  - Generic Transcription Pathway (Rattus norvegicus)
    - Transcriptional Regulation by TP53 (Rattus norvegicus)
      - Regulation of TP53 Activity (Rattus norvegicus)
        
        Regulation of TP53 Activity through Acetylation (Rattus norvegicus)
        
        MTA2-NuRD complex deacetylates TP53 (Rattus norvegicus)
        
        MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - PTEN Regulation (Rattus norvegicus)
      - Regulation of PTEN gene transcription (Rattus norvegicus)
        
        SALL4 recruits NuRD to PTEN gene (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Rattus norvegicus)
        
        SALL4:NuRD [nucleoplasm] (Rattus norvegicus)
        
        NuRD complex [nucleoplasm] (Rattus norvegicus)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)
        
        Mta2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F7F888

Gene Names

Mta2

Reference Genes

ENSEMBL:ENSRNOG00000019913

ENSEMBL:ENSRNOG00000019913.6 Mta2

Other Identifiers

10713760

1373103_at

1373527_at

17623873

361724

5623813

5638488

5677478

5686147

5718134

5781351

5784670

5790279

5808654

5810785

5819384

5900222

5903191

5957502

6060304

6122574

6139405

6161523

6169337

6236087

6365467

6454497

6691377

6715814

A_42_P788749

A_44_P1051799

A_64_P157425

GE17864

GE19336

GO:0000118

GO:0000122

GO:0000781

GO:0003677

GO:0003682

GO:0003712

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006306

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016581

GO:0016787

GO:0036211

GO:0043226

GO:0043565

GO:0045892

GO:0045944

GO:0061629

GO:0140096

GO:0140110

ILMN_1351228

ILMN_1361751

PH_rn_0011639

PH_rn_0017871

rc_AA997050_at

rc_AI102879_at

Participates

as a component of

MTA2-NuRD complex [nucleoplasm] (Rattus norvegicus)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Rattus norvegicus)

Inferred From

MTA2 [nucleoplasm] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000027141, ENSRNOG00000019913, ENSRNOP00000027141

RGD

1306743

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