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APEX1 [nucleoplasm]
Stable Identifier
R-RNO-50119
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P43138
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of DNA glycosylase by APEX1 (Rattus norvegicus)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
Oxidative damage to the AP site (Rattus norvegicus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
PCNA-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
LIG1 binds APEX1 and PCNA at SSB (Rattus norvegicus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
LIG1 bound to APEX1 and PCNA ligates SSB (Rattus norvegicus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1 (Rattus norvegicus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLD,POLE-mediated DNA strand displacement synthesis (Rattus norvegicus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Recruitment of POLB to oxidatively damaged AP site (Rattus norvegicus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Resolution of AP sites via the single-nucleotide replacement pathway (Rattus norvegicus)
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway (Rattus norvegicus)
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
Recruitment of POLB to the AP site (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P43138
Reference Genes
BioGPS Gene:79116
ENSEMBL:ENSRNOG00000009663
ENSEMBL:ENSRNOG00065000540
KEGG Gene (Rattus norvegicus):79116
Monarch:79116
NCBI Gene:79116
UCSC:P43138
Reference Transcript
RefSeq:XM_006251913.1
RefSeq:NM_024148.1
Participates
as an output of
Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break (Rattus norvegicus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)
as a component of
LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:SSB(5'-ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
APEX1:AP-dsDNA [nucleoplasm] (Rattus norvegicus)
as an input of
Displacement of TDG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of SMUG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of UNG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MPG glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of OGG1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MUTYH glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of NTHL1 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Displacement of MBD4 glycosylase by APEX1 at the AP site (Rattus norvegicus)
Inferred From
APEX1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006251975.1
,
NP_077062.1
PRO
P43138
RGD
2126
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