Reactome | Ncbp2 [nucleoplasm]

Ncbp2 [nucleoplasm]

Stable Identifier

R-RNO-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

NCBP2, B1WC40

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - RNA Polymerase II Pre-transcription Events (Rattus norvegicus)
    - Abortive termination of early transcription elongation by DSIF:NELF (Rattus norvegicus)
      - DSIF:NELF:early elongation complex [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
  - RNA Polymerase II Transcription Elongation (Rattus norvegicus)
    - Formation of RNA Pol II elongation complex (Rattus norvegicus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
    - Formation of the Early Elongation Complex (Rattus norvegicus)
      - DSIF complex binds to RNA Pol II (hypophosphorylated) (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - Formation of DSIF:NELF:early elongation complex (Rattus norvegicus)
        
        DSIF:NELF:early elongation complex [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm] (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Rattus norvegicus)
        
        RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
        
        capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
  - RNA Polymerase II Transcription Termination (Rattus norvegicus)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Rattus norvegicus)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Rattus norvegicus)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        capped intronless pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
    - Cleavage of mRNA at the 3'-end (Rattus norvegicus)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
    - Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA (Rattus norvegicus)
      - Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP:ZFP100 Complex [nucleoplasm] (Rattus norvegicus)
        
        Capped Intronless Histone pre-mRNA:CBP80:CBP20:SLBP [nucleoplasm] (Rattus norvegicus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - Mature Intronless transcript derived Histone mRNA:SLBP:CBP80:CBP20 [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
    - Cleavage of the 3'-end of the Histone Pre-mRNA (Rattus norvegicus)
      - Capped Intronless Histone pre-mRNA:CBC:ZFP100 Complex [nucleoplasm] (Rattus norvegicus)
        
        Capped Intronless Histone pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - Mature intronless transcript derived Histone pre-mRNA:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
  - RNA polymerase II transcribes snRNA genes (Rattus norvegicus)
    - Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
      - CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        CBCAP:capped pre-snRNA [nucleoplasm] (Rattus norvegicus)
        
        Cap Binding Complex (CBC) [nucleoplasm] (Rattus norvegicus)
        
        Ncbp2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B1WC40

Gene Names

Ncbp2

Reference Genes

BioGPS Gene:689116 Ncbp2

ENSEMBL:ENSRNOG00000001746

ENSEMBL:ENSRNOG00000001746 Ncbp2

ENSEMBL:ENSRNOG00000048589

ENSEMBL:ENSRNOG00000048589 Ncbp2

KEGG Gene (Rattus norvegicus):689116 Ncbp2

Monarch:689116 Ncbp2

NCBI Gene:689116 Ncbp2

UCSC:B1WC40 Ncbp2

Reference Transcript

RefSeq:NM_001109525.1 Ncbp2

Other Identifiers

103690107

10754871

108348149

1383965_at

1385553_at

1392858_at

17669853

5749440

6054657

6271716

6352957

6505061

6556414

6595125

689116

A_44_P1019826

A_64_P157430

GE1168683

GO:0000339

GO:0003674

GO:0003676

GO:0003723

GO:0005575

GO:0005622

GO:0005846

GO:0006397

GO:0008150

GO:0032991

GO:0034641

GO:0045292

ILMN_1362011

PH_rn_0006223

rc_AA893307_at

Participates

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Rattus norvegicus)

as a component of

as an input of

Formation of cap binding complex (CBC) (Rattus norvegicus)

Other forms of this molecule

Ncbp2 [cytosol]

Inferred From

NCBP2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001102995.1

Ensembl

ENSRNOT00000071483, ENSRNOG00000048589, ENSRNOP00000002381, ENSRNOP00000066677, ENSRNOT00000002381, ENSRNOG00000001746

PRO

B1WC40

RGD

1596188

Cite Us!