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About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
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How do I search ?
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Fn1 [extracellular region]
Stable Identifier
R-RNO-54851
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
FN1(32-2386), P04937
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Rattus norvegicus)
Degradation of the extracellular matrix (Rattus norvegicus)
Fibronectin degradation by ADAM8 (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fibronectin degradation by CTSG (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fibronectin degradation by MMP14, TMPRSS6 (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
ECM proteoglycans (Rattus norvegicus)
Tenascins C, R, (X, N) bind fibronectin matrix (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Tenascins C, R, (X, N):Fibronectin matrix [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Elastic fibre formation (Rattus norvegicus)
Molecules associated with elastic fibres (Rattus norvegicus)
Fibulin-1 and -2 bind fibronectin (Rattus norvegicus)
FBLN1, FBLN2:Fibronectin matrix [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
FN1 binds Collagen types I-V, VII (Rattus norvegicus)
FN1(32-2386):Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fibronectin matrix formation (Rattus norvegicus)
FN1 aggregation (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha5beta1:Fibronectin matrix [plasma membrane] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
FN1 dimerizes (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin cell surface interactions (Rattus norvegicus)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Interaction of integrin alphaIIbbeta3 with Fibronectin (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha2bbeta3:FN1(32-2386) [plasma membrane] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Non-integrin membrane-ECM interactions (Rattus norvegicus)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Rattus norvegicus)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Rattus norvegicus)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Syndecan interactions (Rattus norvegicus)
Syndecan-1 binds fibronectin (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Syndecan-1:Fibronectin matrix [plasma membrane] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Integrin alpha5beta1 binds FN1 dimer (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alpha5beta1:FN1 dimer [plasma membrane] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Response to elevated platelet cytosolic Ca2+ (Rattus norvegicus)
Platelet degranulation (Rattus norvegicus)
Exocytosis of platelet alpha granule contents (Rattus norvegicus)
Platelet alpha granule contents [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Autophosphorylation of SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Clustering of Integrin alphaIIb beta3 complexes (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Phosphorylation of pPTK2 by SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Release of CSK from SRC (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Recruitment of BCAR1 to PTK2 complex (Rattus norvegicus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
Focal Adhesion/Focal contacts [plasma membrane] (Rattus norvegicus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Rattus norvegicus)
Focal complex [plasma membrane] (Rattus norvegicus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates PTK2 signaling (Rattus norvegicus)
PTK2 binds activated MET (Rattus norvegicus)
Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Rattus norvegicus)
Collagen, laminin, fibronectin [extracellular region] (Rattus norvegicus)
Fibronectin matrix [extracellular region] (Rattus norvegicus)
FN1 dimer [extracellular region] (Rattus norvegicus)
Fn1 [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P04937
Gene Names
Fn1
Reference Genes
ENSEMBL:ENSRNOG00000014288
UCSC:P04937 Fn1
Participant Of
hasMember
Integrin alphaIIb beta3 ECM ligands [extracellular region]
Platelet alpha granule contents [extracellular region]
input
FN1 aggregation
FN1 binds Collagen types I-V, VII
FN1 dimerizes
Interaction of integrin alphaIIbbeta3 with Fibronectin
hasComponent
FN1 dimer [extracellular region]
FN1(32-2386):Collagen types I-V, VII [extracellular region]
Integrin alpha2bbeta3:FN1(32-2386) [plasma membrane]
Other forms of this molecule
Fn1 [platelet alpha granule lumen]
Fn1 [extracellular region]
Fn1 [extracellular region]
Fn1 [extracellular region]
Fn1 [extracellular region]
phospho-Fn1 [endoplasmic reticulum lumen]
Fn1 [endoplasmic reticulum lumen]
Inferred From
FN1(32-2386) [extracellular region] (Homo sapiens)
Cross References
PRO
P04937
RGD
2624
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34901 Sdc4
26
Sdc4 [plasma membrane]
(R-RNO-2090061)
Sdc4 [plasma membrane]
(R-RNO-2750170)
Sdc4 [lysosomal lumen]
(R-RNO-2090041)
Sdc4 [lysosomal lumen]
(R-RNO-2090058)
Sdc4 [Golgi lumen]
(R-RNO-2076330)
Sdc4 [Golgi lumen]
(R-RNO-2076510)
Sdc4 [Golgi lumen]
(R-RNO-2076374)
Sdc4 [Golgi lumen]
(R-RNO-2076394)
Sdc4 [plasma membrane]
(R-RNO-2076670)
Sdc4 [plasma membrane]
(R-RNO-2076653)
Sdc4 [plasma membrane]
(R-RNO-2076635)
Sdc4 [plasma membrane]
(R-RNO-2076633)
Sdc4 [plasma membrane]
(R-RNO-2076694)
Sdc4 [plasma membrane]
(R-RNO-2076674)
Sdc4 [Golgi lumen]
(R-RNO-2064195)
Sdc4 [Golgi lumen]
(R-RNO-2064249)
Sdc4 [Golgi lumen]
(R-RNO-2054111)
Sdc4 [Golgi lumen]
(R-RNO-2064100)
Sdc4 [Golgi lumen]
(R-RNO-2064067)
Sdc4 [Golgi lumen]
(R-RNO-2076418)
Sdc4 [Golgi lumen]
(R-RNO-2076407)
Sdc4 [Golgi lumen]
(R-RNO-2076411)
Sdc4 [Golgi lumen]
(R-RNO-2076434)
Sdc4 [Golgi lumen]
(R-RNO-2076613)
Sdc4 [Golgi lumen]
(R-RNO-2076460)
Sdc4 [Golgi lumen]
(R-RNO-2076446)
0.524
2
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