Reactome | SRC_RAT [cytosol]

SRC_RAT [cytosol]

Stable Identifier

R-RNO-548926

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase Src, Src

Locations in the PathwayBrowser

Expand all

Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - EPH-Ephrin signaling (Rattus norvegicus)
      - EPH-ephrin mediated repulsion of cells (Rattus norvegicus)
        
        EPHA binds TIAM1 (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        SFKs phosphorylate VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        p-EPHs bind VAV2,3 (Rattus norvegicus)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
      - EPHA-mediated growth cone collapse (Rattus norvegicus)
        
        NGEF exchanges GTP for GDP on RHOA (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs:p-Y179-NGEF [plasma membrane] (Rattus norvegicus)
        
        EFNAs:p-EPHAs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
      - EPHB-mediated forward signaling (Rattus norvegicus)
        
        EPHB phosphorylates TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHB:NMDAR binds TIAM1 (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Rattus norvegicus)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN,YES,LYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
      - Ephrin signaling (Rattus norvegicus)
        
        EFNB:GRB4 binds GIT1 (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EFNBs bind SFKs (Rattus norvegicus)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        GIT1 binds bPIX (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        PAK binds RAC and bPIX (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        PAKs autophosphorylate (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        PAKs phosphorylate MLC (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        bPIX exchanges GTP for GDP on RAC, activating it (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        p-EFNB binds GRB4 (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Rattus norvegicus)
        
        EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Rattus norvegicus)
        
        SRC,FYN [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
    - L1CAM interactions (Rattus norvegicus)
      - Recycling pathway of L1 (Rattus norvegicus)
        
        Phosphorylation of L1 by SRC (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
    - RET signaling (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Rattus norvegicus)
        
        SRC-1, RAP1GAP [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)
        
        SRC-1, RAP1GAP [cytosol] (Rattus norvegicus)
        
        SRC_RAT [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9WUD9 Src

Gene Names

Src

Chain

initiator methionine:1, chain:2-536

Reference Genes

BioGPS Gene:83805 Src

KEGG:rno:83805 Src

Monarch:83805 Src

NCBI Gene:83805 Src

UCSC:Q9WUD9 Src

Reference Transcript

Other Identifiers

10841624

1368830_at

1373124_at

1387352_at

1389030_a_at

17768262

5708335

5759376

5763932

5775253

5876040

6059878

6108039

6316822

6322140

6330085

6386753

6481263

6483342

6503327

6549699

6658434

6676184

6691130

6725745

83805

A_43_P12708

A_64_P042955

GE13400

GE21437

GO:0000122

GO:0002376

GO:0003013

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005178

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005743

GO:0005764

GO:0005768

GO:0005770

GO:0005829

GO:0005886

GO:0005901

GO:0005911

GO:0006355

GO:0006468

GO:0007179

GO:0007229

GO:0010632

GO:0010634

GO:0016004

GO:0016579

GO:0016740

GO:0019899

GO:0020037

GO:0022407

GO:0030054

GO:0030163

GO:0031333

GO:0031669

GO:0032205

GO:0034138

GO:0034139

GO:0034330

GO:0034614

GO:0035306

GO:0035331

GO:0035556

GO:0038202

GO:0042169

GO:0042311

GO:0043066

GO:0043149

GO:0043161

GO:0043274

GO:0044325

GO:0045747

GO:0046875

GO:0048041

GO:0048471

GO:0048856

GO:0051057

GO:0051219

GO:0051897

GO:0051902

GO:0060576

GO:0070102

GO:0070555

GO:0070700

GO:0097110

GO:0098772

GO:0140096

GO:1902564

GO:1904262

GO:1904263

GO:2000394

GO:2000641

GO:2000811

GO:2001237

GO:2001243

GO:2001286

ILMN_1349852

PH_rn_0012176

rc_AA943307_g_at

rc_AA956919_at

rc_AI011267_at

rc_AI179933_at

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

phospho-Src [plasma membrane]

Src [plasma membrane]

phospho-Src [plasma membrane]

phospho-Src [cytosol]

phospho-Src [plasma membrane]

MyrG-p-Y419-Src [plasma membrane]

Src [plasma membrane]

Src [cytosol]

phospho-Src [cytosol]

MyrG,p-Y419-Src [plasma membrane]

Inferred From

Activated SRC-1 [cytosol] (Homo sapiens)

SRC-2 [cytosol] (Homo sapiens)

SRC-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017447555.1, XP_017447554.1, XP_017447557.1, XP_017447558.1, XP_017447559.1, XP_017447556.1, XP_038961886.1, XP_038961889.1, NP_001418422.1, XP_038961891.1, XP_008760609.1, XP_038961893.1, XP_038961892.1, NP_114183.1, XP_038961890.1, NP_001418421.1, NP_001418420.1, NP_001418419.1, XP_008760610.1, XP_038961888.1, XP_063140743.1, XP_063140742.1, XP_063140739.1, NP_001418418.1, XP_017447561.1, XP_063140746.1, XP_017447560.1, XP_063140745.1, XP_063140736.1, XP_063140734.1, XP_063140738.1, XP_063140735.1, XP_063140737.1

ENSEMBL

ENSRNOP00000071837, ENSRNOG00000009495, ENSRNOT00000012739, ENSRNOT00000080516, ENSRNOP00000012739

IntEnz

2.7.10.2

ZINC - Substances

SRC_RAT

ZINC target

Q9WUD9

PRO

Q9WUD9

RGD

620795

ZINC - Predictions - Purchasable

SRC_RAT

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22002 Cacna1c	2	Voltage-dependent L-type calcium channel subunit alpha-1C [plasma membrane] (R-RNO-446483) Cacna1c [plasma membrane] (R-RNO-265551)	0.591	4
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.564	2
UniProt:Q63767	4	phospho-Bcar1 [cytosol] (R-RNO-372645) phospho-Bcar1 [cytosol] (R-RNO-8848723) Bcar1 [cytosol] (R-RNO-201625) phospho-Bcar1 [cytosol] (R-RNO-5218739)	0.558	2
UniProt:O08617 PTPRR			0.544	2

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