Reactome | MARK3 [cytosol]

MARK3 [cytosol]

Stable Identifier

R-RNO-5672591

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Q8VHF0

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        Dissociation of RAS:RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        RAF phosphorylates MAP2K dimer (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
      - Negative regulation of MAPK pathway (Rattus norvegicus)
        
        BRAP binds KSR1:MARK3 (Rattus norvegicus)
        
        BRAP:KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
      - RAF activation (Rattus norvegicus)
        
        MARK3 phosphorylates KSR1 (Rattus norvegicus)
        
        KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        PP2A dephosphorylates KSR1 (Rattus norvegicus)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Phosphorylation of RAF (Rattus norvegicus)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Rattus norvegicus)
        
        activated RAF/KSR1 [plasma membrane] (Rattus norvegicus)
        
        p-S311,T602 KSR1:MARK3 [plasma membrane] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Rattus norvegicus)
        
        BRAP:KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        Raf dimer inhibitors bind RAF heterodimers (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Rattus norvegicus)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Rattus norvegicus)
        
        dephosphorylated "receiver" RAF/KSR1 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        YWHAB dimer dissociates from KSR1:MARK3 (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3:YWHAB dimer [plasma membrane] (Rattus norvegicus)
        
        p-S311 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3 binds YWHAB dimer (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3:YWHAB dimer [cytosol] (Rattus norvegicus)
        
        p-S311,S406 KSR1:MARK3 [cytosol] (Rattus norvegicus)
        
        MARK3 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q8VHF0

Reference Genes

BioGPS Gene:170577

ENSEMBL:ENSRNOG00000010330

KEGG Gene (Rattus norvegicus):170577

Monarch:170577

NCBI Gene:170577

UCSC:Q8VHF0

Reference Transcript

RefSeq:NM_130749.1

Participates

as a component of

Inferred From

MARK3 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_570105.1

PRO

Q8VHF0

RGD

619883

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