Reactome | Cnksr2 [cytosol]

Cnksr2 [cytosol]

Stable Identifier

R-RNO-5672632

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

CNKSR2, Q9Z1T4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        Dissociation of RAS:RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        RAF phosphorylates MAP2K dimer (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
        
        RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)
        
        Cnksr2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9Z1T4

Gene Names

Cnksr2

Reference Genes

BioGPS Gene:59322 Cnksr2

ENSEMBL:ENSRNOG00000007014

KEGG:rno:59322 Cnksr2

Monarch:59322 Cnksr2

NCBI Gene:59322 Cnksr2

UCSC:Q9Z1T4 Cnksr2

Reference Transcript

Other Identifiers

10933609

1369731_at

1370668_a_at

17872391

5663930

5674325

5716588

5768179

5777917

5795514

5868911

5901731

5925509

59322

5950414

5999166

6024800

6062750

6081419

6095373

6195527

6242843

6333084

6373803

6390515

6392583

6403899

6439988

6457139

6468355

6487675

6514777

6540582

6545090

6613127

6622052

6666458

6689834

6723794

AF102853_at

AF102853_g_at

AF102854_at

A_44_P178576

A_44_P196440

GE13341

GO:0005515

GO:0005737

GO:0005886

GO:0009966

GO:0014069

GO:0016020

GO:0019901

GO:0023052

GO:0035556

GO:0043226

ILMN_1348904

PH_rn_0015147

PH_rn_0018512

Participates

as a candidate of

RAF/MAPK scaffolds [cytosol] (Rattus norvegicus)

Inferred From

CNKSR2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_067718.1, NP_001106837.1

ENSEMBL

ENSRNOT00000080512, ENSRNOT00000009802, ENSRNOP00000009802, ENSRNOP00000071915

PRO

Q9Z1T4

RGD

708454

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [plasma membrane] (R-RNO-9612601) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [cytosol] (R-RNO-6794248)	0.556	4
UniProt:Q96NW7 LRRC7	3	LRRC7 [extracellular region] (R-HSA-6799681) LRRC7 [specific granule lumen] (R-HSA-6799616) LRRC7 [cytosol] (R-HSA-9611351)	0.508	2

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