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PDPK1 [plasma membrane]
Stable Identifier
R-RNO-61459
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
plasma membrane
Synonyms
O55173
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
PDPK1 phosphorylates SGK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Activation of IKK complex (Rattus norvegicus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Rattus norvegicus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Activation of TAK1-TAB2 complex (Rattus norvegicus)
TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane] (Rattus norvegicus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Ub-TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Interaction and oligomerization of MALT1 to Bcl10 (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Interaction of Bcl10 to CARMA1 (Rattus norvegicus)
Bcl10 bound to CARMA1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Oligomerization of Bcl10 (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Oligomerization of CARMA1 (Rattus norvegicus)
Activated CARMA1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of Bcl10 (Rattus norvegicus)
Bcl10 bound to CARMA1 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Phosphorylated Bcl10 bound to CARMA1 and RIP2 [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of CARMA1 (Rattus norvegicus)
Activated CARMA1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
CARMA1 bound to PDK1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Phosphorylation of PKC theta (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Translocation of CARMA1 to Plasma membrane (Rattus norvegicus)
CARMA1 bound to PDK1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
TRAF6 trimer bound to CBM complex [plasma membrane] (Rattus norvegicus)
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane] (Rattus norvegicus)
Bcl10 trimer bound to CARMA1 trimer [plasma membrane] (Rattus norvegicus)
CARMA1 trimer [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding (Rattus norvegicus)
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1 binds PIP2 (Rattus norvegicus)
PDPK1:PIP2 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1 phosphorylates SGK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
PDK1:AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
Estrogen-stimulated signaling through PRKCZ (Rattus norvegicus)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PRKCZ autophosphorylates downstream of estrogen stimulation (Rattus norvegicus)
PDPK1:PIP3:p-T410-PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PRKCZ recruits RAS in response to estrogen stimulation (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
Activation of AKT2 (Rattus norvegicus)
PDPK1 binds PIP3 (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1 phosphorylates AKT2 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
Activation of AKT2 (Rattus norvegicus)
PDPK1 binds PIP3 (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PDPK1 phosphorylates AKT2 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated cell proliferation (Rattus norvegicus)
PDK1 phosphorylates PKC (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT binds PDPK1 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
p-S-AKT:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases activate PKNs (Rattus norvegicus)
PDPK1 phosphorylates PKN1,2,3 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3 (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
RHOA,RHOB,RHOC,RAC1:GTP:PKN1-3:PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1 [plasma membrane] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O55173 Pdpk1
Gene Names
Pdpk1, Pdk1
Chain
chain:1-559
Reference Genes
BioGPS Gene:81745 Pdpk1
ENSEMBL:ENSRNOG00000006136.6 Pdpk1
ENSEMBL:ENSRNOG00055026228 Pdpk1
ENSEMBL:ENSRNOG00060009727 Pdpk1
ENSEMBL:ENSRNOG00065010212 Pdpk1
KEGG Gene (Rattus norvegicus):81745 Pdpk1
Monarch:81745 Pdpk1
NCBI Gene:81745 Pdpk1
UCSC:O55173 Pdpk1
Reference Transcript
RefSeq:NM_031081.1 Pdpk1
Other Identifiers
10740966
1370052_at
17654277
5697325
5716279
5796066
6144274
6157614
6167593
6196715
6212278
6286075
6346236
6429765
6497706
6542372
6580199
6736894
6737108
81745
A_44_P258751
GE22243
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0006468
GO:0016740
GO:0036211
GO:0140096
ILMN_1359177
PH_rn_0003053
Y15748_at
Participates
as a member of
AKT1/PDK1 [plasma membrane] (Rattus norvegicus)
as a component of
PDK1:AKT:PIP3 [plasma membrane] (Rattus norvegicus)
PDK1:PIP2,PIP3 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP2 [plasma membrane] (Rattus norvegicus)
PDPK1:PIP3 [plasma membrane] (Rattus norvegicus)
as an input of
PDPK1 binds PIP3 (Rattus norvegicus)
Other forms of this molecule
Pdk1 [plasma membrane]
PDPK1 [cytosol]
Inferred From
PDPK1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_112343.1
Ensembl
ENSRNOP00000061683
,
ENSRNOG00000006136
,
ENSRNOT00000067660
PRO
O55173
RGD
620307
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