Phosphorylation of PLCgamma by Netrin-1

Stable Identifier
R-RNO-622372
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of PLCgamma by Netrin-1

Netrin-1-DCC mediated signaling rapidly phosphorylates PLCgamma. Netrin-1 mediated PLC activation depends on recruitment of PITPalpha to DCC. Stimulation of PLC signaling and hydrolysis of PIP2 by netrin-1 in neurons is time-dependent, with a maximal activity observed within 15 min of netrin-1 stimulation.

Literature References
PubMed ID Title Journal Year
16321979 DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation

Xie, Y, Hong, Y, Ma, XY, Ren, XR, Ackerman, S, Mei, L, Xiong, WC

J Biol Chem 2006
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created
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