Reactome | Sos1 [cytosol]

Sos1 [cytosol]

Stable Identifier

R-RNO-64847

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

SOS1, D4A3T0

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
    - Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
      - p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)
        
        BLNK:GRB2:SOS1:CIN85 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
- Cytokine Signaling in Immune system (Rattus norvegicus)
  - FLT3 Signaling (Rattus norvegicus)
    - SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Rattus norvegicus)
      - Active FLT3:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Sos1 [cytosol] (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Interleukin-15 signaling (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Rattus norvegicus)
        
        IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        SOS1, SOS2 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        SOS1, SOS2 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
- Innate Immune System (Rattus norvegicus)
  - DAP12 interactions (Rattus norvegicus)
    - DAP12 signaling (Rattus norvegicus)
      - Activation of RAC1 by VAV2/3 (Rattus norvegicus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of BTK by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of VAV and BTK to p-SLP-76 (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Release of p-PLCG1 (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
  - Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
    - FCERI mediated Ca+2 mobilization (Rattus norvegicus)
      - Autophosphorylation of BTK/ITK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
    - FCERI mediated MAPK activation (Rattus norvegicus)
      - Activation of RAC1 by VAV (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Autophosphorylation of PAK (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Interaction of GRB2:SOS complex with p-SHC1 (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation and activation of VAV (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of GADS:SLP-76 to p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of GRB2:SOS to p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of VAV to p-SLP-76 (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - SOS mediated nucleotide exchange of RAS (SHC) (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
      - PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
      - Recruitment of GRB2:SOS to p-10Y-NTAL (Rattus norvegicus)
        
        p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)
        
        p-SHC1:GRB2:SOS [cytosol] (Rattus norvegicus)
        
        GRB2-1:SOS1 [cytosol] (Rattus norvegicus)
        
        Sos1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A3T0 Sos1

Gene Names

Sos1, rCG_62427

Reference Genes

BioGPS Gene:313845 Sos1

ENSEMBL:ENSRNOG00000007106.8 Sos1

KEGG Gene (Rattus norvegicus):313845 Sos1

Monarch:313845 Sos1

NCBI Gene:313845 Sos1

Reference Transcript

RefSeq:NM_001100716.1 Sos1

Other Identifiers

10888021

1385959_at

1389710_at

1390864_at

17819751

313845

5668316

5678337

5681322

5683687

5778488

5795346

5808030

5849583

5855415

5893343

5930173

5953246

5997414

6014183

6048993

6077637

6097226

6226405

6268186

6291476

6337877

6371738

6454370

6514531

6523117

6593679

6642845

6643998

6665347

6665691

6681486

6706804

6710242

6722851

A_43_P14954

A_64_P018142

GO:0001782

GO:0001942

GO:0002260

GO:0002376

GO:0003007

GO:0003209

GO:0003344

GO:0005085

GO:0005737

GO:0006351

GO:0006355

GO:0006357

GO:0007173

GO:0007264

GO:0007265

GO:0007296

GO:0008286

GO:0008543

GO:0014044

GO:0022414

GO:0023052

GO:0030154

GO:0033081

GO:0035264

GO:0042127

GO:0042129

GO:0042552

GO:0046982

GO:0048009

GO:0048514

GO:0048856

GO:0050853

GO:0060021

GO:0060090

GO:0061029

GO:0061384

GO:0098772

GO:0140693

GO:1904693

GO:1905360

GO:2000973

ILMN_1350972

PH_rn_0011793

rc_AA892860_at

rc_AA892860_g_at

rc_AI176851_at

Participates

as a candidate of

as an input of

as a component of

as a member of

GEFs [cytosol] (Rattus norvegicus)

Other forms of this molecule

Sos1 [cytosol]

phospho-Sos1 [cytosol]

Sos1 [plasma membrane]

Inferred From

SOS1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001094186.1

Ensembl

ENSRNOT00000009359, ENSRNOG00000007106, ENSRNOP00000009359

RGD

1310949

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