Reactome | Ppie [nucleoplasm]

Ppie [nucleoplasm]

Stable Identifier

R-RNO-6781959

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

PPIE, B0BMU0

Locations in the PathwayBrowser

Expand all

DNA Repair (Rattus norvegicus)

- Nucleotide Excision Repair (Rattus norvegicus)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Rattus norvegicus)
    - Dual incision in TC-NER (Rattus norvegicus)
      - 3' incision by ERCC5 (XPG) in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Rattus norvegicus)
        
        TC-NER incision complex [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Rattus norvegicus)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
        
        TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - ERCC5 and RPA bind TC-NER site (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
    - Formation of TC-NER Pre-Incision Complex (Rattus norvegicus)
      - UVSSA:USP7 deubiquitinates ERCC6 (Rattus norvegicus)
        
        TC-NER pre-incision complex [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Rattus norvegicus)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Rattus norvegicus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Rattus norvegicus)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Rattus norvegicus)
        
        XAB2 complex [nucleoplasm] (Rattus norvegicus)
        
        Ppie [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B0BMU0

Gene Names

Ppie

Reference Genes

BioGPS Gene:298508 Ppie

ENSEMBL:ENSRNOG00000014762

ENSEMBL:ENSRNOG00000014762 Ppie

Monarch:298508 Ppie

NCBI Gene:298508 Ppie

Reference Transcript

RefSeq:XM_006238796.3 Ppie

Other Identifiers

10879530

1389055_at

17810291

298508

5789469

5812771

5846550

5997584

6021767

6114783

6284262

6303712

6308406

6419659

6419843

6541888

A_44_P205721

A_64_P108140

GE14011

GO:0000398

GO:0000413

GO:0003674

GO:0003676

GO:0003723

GO:0003729

GO:0003755

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006397

GO:0006457

GO:0006464

GO:0008143

GO:0008150

GO:0009058

GO:0016018

GO:0016607

GO:0016853

GO:0032991

GO:0034641

GO:0043226

GO:0044403

GO:0045070

GO:0071007

GO:0071013

ILMN_1350624

rc_AI104479_at

Participant Of

input

Formation of the Spliceosomal B Complex

hasComponent

Other forms of this molecule

Ppie [ficolin-1-rich granule lumen]

Ppie [extracellular region]

Ppie [secretory granule lumen]

Inferred From

PPIE [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006238858.1

Ensembl

ENSRNOP00000074074, ENSRNOT00000089980, ENSRNOG00000014762

RGD

1311411

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