Reactome | HSPA1A [nucleoplasm]

HSPA1A [nucleoplasm]

Stable Identifier

R-RNO-6792605-2

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

P0DMW1

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Rattus norvegicus)

- Cellular responses to stress (Rattus norvegicus)
  - Cellular response to heat stress (Rattus norvegicus)
    - HSF1-dependent transactivation (Rattus norvegicus)
      - Attenuation phase (Rattus norvegicus)
        
        HSF1 acetylation at Lys80 (Rattus norvegicus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 binds HSF1 (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
      - HSF1-mediated gene expression (Rattus norvegicus)
        
        Heat shock inducible proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
    - Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
      - HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Rattus norvegicus)
        
        HSP70s:ADP [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A:ADP [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Rattus norvegicus)
        
        HSP70s:ATP [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A:ATP [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
      - NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Rattus norvegicus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Rattus norvegicus)
        
        HSP70s:ATP [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A:ATP [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
      - SIRT1 binds to HSF1 (Rattus norvegicus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
      - SIRT1 deacetylates HSF1 (Rattus norvegicus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Rattus norvegicus)
        
        HSP70:DNAJB1 [nucleoplasm] (Rattus norvegicus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Rattus norvegicus)
        
        Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)
        
        HSPA1A [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P0DMW1

Reference Genes

BioGPS Gene:108348108

BioGPS Gene:24472

ENSEMBL:ENSRNOG00000045654

ENSEMBL:ENSRNOG00000050647

KEGG Gene (Rattus norvegicus):108348108

KEGG Gene (Rattus norvegicus):24472

Monarch:108348108

Monarch:24472

NCBI Gene:108348108

NCBI Gene:24472

Reference Transcript

Participates

as a member of

Homologues of HSPA1A [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

HSPA1A [cytosol]

HSPA1A [extracellular region]

HSPA1A [ficolin-1-rich granule lumen]

Inferred From

HSPA1B [nucleoplasm] (Homo sapiens)

HSPA1A [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_114177.2, XP_017457331.1, NP_997669.1, NP_001316825.1

PRO

P0DMW1

RGD

1593284, 2840