Shank1,3 binds Homer1a

Stable Identifier
R-RNO-6794343
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Shank1,3 binds Homer1a
Homer with its EVH1 domain binds to proline-rich motif of Shank family members. Shank and Homer coimmunoprecipitate from brain and colocalize at postsynaptic densities. Shank uses distinct domains to bind to GKAP and Homer, thus it can bridge between these two proteins. Thus, Shank may cross-link Homer and PSD-95 complexes in the PSD and play a role in the signaling mechanisms of both mGluRs and NMDA receptors (Tu et al. 1999).
Literature References
PubMed ID Title Journal Year
10433269 Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins

Sheng, M, Petralia, RS, Tu, JC, Aakalu, VK, Brakeman, P, Doan, A, Naisbitt, S, Yuan, JP, Xiao, B, Worley, PF, Lanahan, AA

Neuron 1999
11498055 Regulation of dendritic spine morphology and synaptic function by Shank and Homer

Sheng, M, Wilson, NR, Piëch, V, Sala, C, Passafaro, M, Liu, G

Neuron 2001
Participants
Input
Output
Orthologous Events
HOMER binds SHANK proteins (Homo sapiens)
Authored
Garapati, P V  (2015-09-04)
Reviewed
Washbourne, P  (2015-11-09)
Created
Garapati, P V  (2015-09-04)
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