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Pdlim5 binds Spar
Stable Identifier
R-RNO-6794358
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
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Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM domain family protein called PDZ and LIM domain 5 (PDLIM5), formerly known as Enigma Homolog (ENH). PDLIM5 is expressed postsynaptically in excitatory pyramidal neurons of the hippocampus and associates with SPAR protein in the brain. In hippocampal neurons, PDLIM5 promotes decreased dendritic spine size, opposite to the effect of SPAR overexpression that causes spine head enlargement.
Single nucleotide polymorphisms in PDLIM5 have been associated with schizophrenia, depression, and bipolar disorder (Kato et al. 2005, Li et al. 2008, Liu et al. 2008), although the physiological functions of PDLIM5 are not well understood.
Literature References
PubMed ID
Title
Journal
Year
19900557
Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage
Evers, DM
,
Pak, DT
,
Herrick, S
,
Udagawa, N
,
Lee, JY
Mol. Cell. Neurosci.
2010
Participants
Input
Pdlim5 [cytosol]
(Rattus norvegicus)
Psd-95:Spar [cytosol]
(Rattus norvegicus)
Output
Psd-95:Spar:Pdlim5 [cytosol]
(Rattus norvegicus)
Orthologous Events
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
Authored
Garapati, P V (2015-09-04)
Reviewed
Washbourne, P (2015-11-09)
Created
Garapati, P V (2015-09-04)
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