Pdlim5 binds Spar

Stable Identifier
R-RNO-6794358
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Pdlim5 binds Spar

Spine-Associated RapGAP (SPAR) interacts with a PDZ-LIM domain family protein called PDZ and LIM domain 5 (PDLIM5), formerly known as Enigma Homolog (ENH). PDLIM5 is expressed postsynaptically in excitatory pyramidal neurons of the hippocampus and associates with SPAR protein in the brain. In hippocampal neurons, PDLIM5 promotes decreased dendritic spine size, opposite to the effect of SPAR overexpression that causes spine head enlargement.
Single nucleotide polymorphisms in PDLIM5 have been associated with schizophrenia, depression, and bipolar disorder (Kato et al. 2005, Li et al. 2008, Liu et al. 2008), although the physiological functions of PDLIM5 are not well understood.

Literature References
PubMed ID Title Journal Year
19900557 Postsynaptic PDLIM5/Enigma Homolog binds SPAR and causes dendritic spine shrinkage

Herrick, S, Evers, DM, Lee, JY, Udagawa, N, Pak, DT

Mol. Cell. Neurosci. 2010
Participants
Orthologous Events
Authored
Reviewed
Created
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