Reactome | Ints8 [nucleoplasm]

Ints8 [nucleoplasm]

Stable Identifier

R-RNO-6807409

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

INTS8, A0A0G2K0V1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - RNA polymerase II transcribes snRNA genes (Rattus norvegicus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
    - Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints8 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2K0V1

Gene Names

Ints8

Reference Genes

ENSEMBL:ENSRNOG00000008124

UCSC:A0A0G2K0V1 Ints8

Other Identifiers

10875434

17805788

5722176

5807292

5819913

5841869

5863510

5865992

5903904

5913049

5914793

5940344

5940806

6033819

6060152

6110425

6115358

6185763

6269952

6315795

6317745

6384956

6429525

6457057

6495425

6510366

6527029

6538697

6638091

6639983

6655022

6678605

6700487

6723737

A_43_P11292

GE1172301

GO:0005634

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0043226

ILMN_1354798

PH_rn_0021009

rc_AI179985_at

Participates

as a component of

Integrator [nucleoplasm] (Rattus norvegicus)

Inferred From

INTS8 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOP00000071592, ENSRNOT00000081395

RGD

1310592