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Orc4 [nucleoplasm]
Stable Identifier
R-RNO-68519
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
ORC4, Q6P9Z8
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
Activation of ATR in response to replication stress (Rattus norvegicus)
Activation of claspin (Rattus norvegicus)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Loading of claspin onto DNA during replication origin firing (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1/S Transition (Rattus norvegicus)
Activation of the pre-replicative complex (Rattus norvegicus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Cdt1 is displaced from the pre-replicative complex (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
MCM10:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA polymerase epsilon binds at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)
MCM10:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
S Phase (Rattus norvegicus)
Synthesis of DNA (Rattus norvegicus)
Switching of origins to a post-replicative state (Rattus norvegicus)
Orc1 removal from chromatin (Rattus norvegicus)
Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA Replication (Rattus norvegicus)
DNA Replication Pre-Initiation (Rattus norvegicus)
Activation of the pre-replicative complex (Rattus norvegicus)
CDK and DDK associate with the Mcm10:pre-replicative complex (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Cdt1 is displaced from the pre-replicative complex (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
MCM10:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA polymerase alpha:primase binds at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
DNA polymerase epsilon binds at the origin (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Rattus norvegicus)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
MCM10:active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
active pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Rattus norvegicus)
MCM10:pre-replicative complex [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Assembly of the pre-replicative complex (Rattus norvegicus)
Assembly of the ORC complex at the origin of replication (Rattus norvegicus)
Formation of ORC(1-5) complex (Rattus norvegicus)
ORC(1-5):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Formation of ORC(1-6) complex (Rattus norvegicus)
ORC(1-5):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
ORC(1-6):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Formation of ORC(2-5) complex (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
CDC6 association with the ORC:origin complex (Rattus norvegicus)
CDC6 association with ORC(1-6) at replication origins (Rattus norvegicus)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-6):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
ORC(1-6):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5):origin of replication [nucleoplasm] (Rattus norvegicus)
ORC(1-5) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
Synthesis of DNA (Rattus norvegicus)
Switching of origins to a post-replicative state (Rattus norvegicus)
Orc1 removal from chromatin (Rattus norvegicus)
Orc1 is phosphorylated by cyclin A/CDK2 (Rattus norvegicus)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
pre-replicative complex [nucleoplasm] (Rattus norvegicus)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
CDC6:ORC:origin complex [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
Orc4 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6P9Z8
Gene Names
Orc4
Reference Genes
BioGPS Gene:295596 Orc4
ENSEMBL:ENSRNOG00000005021
KEGG:rno:295596 Orc4
Monarch:295596 Orc4
NCBI Gene:295596 Orc4
UCSC:Q6P9Z8 Orc4
Reference Transcript
RefSeq:NM_001429833.1 Orc4
RefSeq:NM_199092.2 Orc4
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Rattus norvegicus)
ORC(2-5) [nucleoplasm] (Rattus norvegicus)
ORC:origin of replication [nucleoplasm] (Rattus norvegicus)
as an input of
Formation of ORC(2-5) complex (Rattus norvegicus)
Inferred From
ORC4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_954523.1
,
NP_001416762.1
PRO
Q6P9Z8
RGD
735212
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