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TP53 [nucleoplasm]
Stable Identifier
R-RNO-69488
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P10361
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
p53-Dependent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Dependent G1 DNA Damage Response (Rattus norvegicus)
Stabilization of p53 (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
G2/M DNA damage checkpoint (Rattus norvegicus)
ATR phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
DNA Damage/Telomere Stress Induced Senescence (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Oncogene Induced Senescence (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Oxidative Stress Induced Senescence (Rattus norvegicus)
MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
DNA Double Strand Break Response (Rattus norvegicus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Association with Co-factors (Rattus norvegicus)
BANP binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53:BANP [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Methylation (Rattus norvegicus)
EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Activity through Phosphorylation (Rattus norvegicus)
AMPK phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
ATM phosphorylates TP53 at S15 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
ATR phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
AURKA phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
CDK2 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
CDK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
MAPKAPK5 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
NUAK1 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
STK11 (LKB1) phosphorylates NUAK1 (Rattus norvegicus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TAF1 phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 binds HIPK1 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:HIPK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 binds STK11 and NUAK1 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer:STK11:NUAK1 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53RK phosphorylates TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
MDM2 binds TP53 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
MDM2 ubiquitinates TP53 (Rattus norvegicus)
p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
USP7 deubiquitinates TP53 and counteracts MDM2 (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Regulation of TP53 Expression (Rattus norvegicus)
TP53 forms homotetramers (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Transcriptional regulation by RUNX3 (Rattus norvegicus)
RUNX3 regulates CDKN1A transcription (Rattus norvegicus)
RUNX3 binds TP53 (Rattus norvegicus)
RUNX3:TP53 tetramer [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Antiviral mechanism by IFN-stimulated genes (Rattus norvegicus)
PKR-mediated signaling (Rattus norvegicus)
p-PKR dimer phosphorylates TP53 tetramer (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP10,USP24,USP42 deubiquitinate TP53 (Rattus norvegicus)
USP10,USP24,USP42:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Rattus norvegicus)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Rattus norvegicus)
TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Rattus norvegicus)
TP53 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P10361
Reference Genes
BioGPS Gene:24842
ENSEMBL:ENSRNOG00000010756
ENSEMBL:ENSRNOG00000010756.8
ENSEMBL:ENSRNOG00055030460
ENSEMBL:ENSRNOG00060028077
ENSEMBL:ENSRNOG00065000306
ENSEMBL:ENSRNOG00065026731
KEGG Gene (Rattus norvegicus):24842
Monarch:24842
NCBI Gene:24842
UCSC:P10361
Reference Transcript
RefSeq:NM_030989.3
RefSeq:XM_006246594.3
RefSeq:XM_006246595.3
Other Identifiers
10734975
1367830_a_at
1367831_at
1370752_a_at
17647477
24842
5636168
5890490
5978761
6076942
6138159
6185752
6247873
6286710
6404266
6447241
6497054
6720814
A_44_P118929
A_64_P113635
A_64_P148728
GE22105
GO:0000976
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0006351
GO:0006355
GO:0006915
GO:0012501
GO:0043226
GO:0051262
GO:0065003
GO:0140110
ILMN_1366265
PH_rn_0012247
X13058_at
Participates
as a component of
USP10,USP24,USP42:TP53 [nucleoplasm] (Rattus norvegicus)
TP53 Tetramer [nucleoplasm] (Rattus norvegicus)
as a member of
TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Rattus norvegicus)
as an input of
TP53 forms homotetramers (Rattus norvegicus)
Other forms of this molecule
TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
polySUMO2,3-K386-TP53 [nucleoplasm]
phospho-Ac-K120,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Ac-K382,p-S15,S20-TP53 [nucleoplasm]
Me2-K373-TP53 [nucleoplasm]
phospho-MeK-370,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
phospho-Me-K382,p-S15,S20-TP53 [nucleoplasm]
phospho-Me1-K372,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S392-TP53 [nucleoplasm]
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
phospho-p-S15,S392-TP53 [nucleoplasm]
phospho-p-S15,S20-TP53 [nucleoplasm]
phospho-p-S15-TP53 [nucleoplasm]
PolyUb-TP53 [cytosol]
PolyUb-TP53 [nucleoplasm]
phospho-p-S37-TP53 [nucleoplasm]
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
Me2K-370,382-TP53 [nucleoplasm]
phospho-p-S315-TP53 [nucleoplasm]
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
phospho-p-T55-TP53 [nucleoplasm]
Inferred From
TP53 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006246657.1
,
NP_112251.2
,
XP_006246656.1
Ensembl
ENSRNOG00000010756
,
ENSRNOP00000047840
,
ENSRNOT00000046490
PRO
P10361
RGD
3889
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