Passive Transport of Anions into Vesicles by Aquaporin-6 (rat)

Stable Identifier
R-RNO-879862
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
transport vesicle membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Passive Transport of Anions into Vesicles by Aquaporin-6 (rat)
Rat Aquaporin-6 (AQP6) passively transports anions with the specificity: nitrate > iodide > bromide > chloride > fluoride. AQP6 weakly transports water. AQP6 is gated by low pH.
Literature References
PubMed ID Title Journal Year
12177001 Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63

Ikeda, M, Beitz, E, Kozono, D, Guggino, WB, Agre, P, Yasui, M

J Biol Chem 2002
12034750 Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation

Hazama, A, Kozono, D, Guggino, WB, Agre, P, Yasui, M

J Biol Chem 2002
15892693 Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells

Beitz, E, Liu, K, Ikeda, M, Guggino, WB, Agre, P, Yasui, M

Biol Cell 2006
10647010 Rapid gating and anion permeability of an intracellular aquaporin

Yasui, M, Hazama, A, Kwon, TH, Nielsen, S, Guggino, WB, Agre, P

Nature 1999
15671159 Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution

Liu, K, Kozono, D, Kato, Y, Agre, P, Hazama, A, Yasui, M

Proc Natl Acad Sci U S A 2005
Participants
Input
Output
Catalyst Activity

monoatomic anion channel activity of Aquaporin-6 [transport vesicle membrane]

Physical Entity
Aquaporin-6 [transport vesicle membrane] (Rattus norvegicus)
Activity
monoatomic anion channel activity (GO:0005253)
Orthologous Events
Aquaporin-6 passively transports anions into vesicles (Homo sapiens)
Authored
May, B  (2010-06-24)
Reviewed
Beitz, E  (2010-06-24)
Calamita, G  (2010-07-15)
Mathai, JC  (2010-07-31)
MacIver, B  (2010-07-31)
Created
May, B  (2010-06-24)
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