Reactome | phospho-Adrb2 [plasma membrane]

phospho-Adrb2 [plasma membrane]

Stable Identifier

R-RNO-8852158

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

pS-ADRB2, P10608

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - ARRB bind GPCRs (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        pS-ADRB2:Catecholamine [plasma membrane] (Rattus norvegicus)
        
        phospho-Adrb2 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P10608

Gene Names

Adrb2

Reference Genes

ENSEMBL:ENSRNOG00000019217

UCSC:P10608 Adrb2

Participant Of

hasComponent

Other forms of this molecule

phospho-Adrb2 [clathrin-coated endocytic vesicle membrane]

Adrb2 [endosome membrane]

Adrb2 [plasma membrane]

Inferred From

pS-ADRB2 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

ZINC - Metabolites

ADRB2_RAT

ZINC - World Drugs

ADRB2_RAT

ZINC - FDA approved

ADRB2_RAT

ZINC - Substances

ADRB2_RAT

ZINC target

P10608

ZINC - Biogenic

ADRB2_RAT

PRO

P10608

ZINC - Predictions - Purchasable

ADRB2_RAT

RGD

2060

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.499	2
UniProt:P19490 Gria1	7	p-S849-Gria1 [plasma membrane] (R-RNO-9620442) Gria1 [endocytic vesicle membrane] (R-RNO-3004479) Gria1 [plasma membrane] (R-RNO-9620440) Gria1 [plasma membrane] (R-RNO-3004495) Gria1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811) Gria1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) Gria1 [endoplasmic reticulum membrane] (R-RNO-5689460)	0.499	3

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