Reactome | Fcho1 [cytosol]

Fcho1 [cytosol]

Stable Identifier

R-RNO-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FCHO1, D3ZIM5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
    - Recruitment of AP-2 complex and clathrin (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        FCHO1,2 dimer [cytosol] (Rattus norvegicus)
        
        FCHO1 dimer [cytosol] (Rattus norvegicus)
        
        Fcho1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZIM5

Gene Names

Fcho1

Reference Genes

BioGPS Gene:290639 Fcho1

ENSEMBL:ENSRNOG00000033912

ENSEMBL:ENSRNOG00000033912.5 Fcho1

Monarch:290639 Fcho1

NCBI Gene:290639 Fcho1

Reference Transcript

Other Identifiers

10790863

1375978_at

17710793

290639

5734407

5773921

5779867

5846590

6031321

6056595

6119508

6169218

6265658

6297211

6310236

6328366

6328699

6336719

6359710

6387705

6445404

6503781

6608177

6667501

6695942

6703652

GE1261350

GO:0002376

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005905

GO:0007155

GO:0016192

GO:0023052

GO:0035612

GO:0043226

GO:0048268

GO:0050852

GO:0050870

GO:0065003

GO:0072583

PH_rn_0008697

rc_AI100789_at

Participates

as a component of

FCHO1 dimer [cytosol] (Rattus norvegicus)

Inferred From

FCHO1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_006252927.1, XP_006252926.1, XP_008769305.1, XP_017455516.1

Ensembl

ENSRNOP00000049715, ENSRNOT00000040464, ENSRNOG00000033912

RGD

1307683

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