Reactome | Fem1a [cytosol]

Fem1a [cytosol]

Stable Identifier

R-RNO-8863141

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

FEM1A, Q4V890

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Rattus norvegicus)
        
        CUL2-box protein [cytosol] (Rattus norvegicus)
        
        Fem1a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q4V890

Gene Names

Fem1a

Reference Genes

BioGPS Gene:316131 Fem1a

ENSEMBL:ENSRNOG00000050646

ENSEMBL:ENSRNOG00000066151

ENSEMBL:ENSRNOG00000066151.1 Fem1a

ENSEMBL:ENSRNOG00055015251

ENSEMBL:ENSRNOG00060019318

ENSEMBL:ENSRNOG00065013637

KEGG Gene (Rattus norvegicus):316131 Fem1a

Monarch:316131 Fem1a

NCBI Gene:316131 Fem1a

Reference Transcript

RefSeq:NM_001025706.1 Fem1a

Other Identifiers

10931475

1372054_at

1398417_at

17869297

316131

5645813

5825514

5871418

5891395

5895765

5964761

6101883

6677215

AA848569_at

A_64_P153277

GE15997

GE19188

GO:0005515

GO:0005739

GO:0006954

GO:0030163

GO:0031462

GO:0031867

GO:0043226

GO:0050728

GO:0060090

GO:0140627

GO:1990756

ILMN_1363936

PH_rn_0015708

rc_AA900474_g_at

rc_AA924913_s_at

rc_AI045581_at

rc_AI638958_at

Participates

as a member of

CUL2-box protein [cytosol] (Rattus norvegicus)

Inferred From

FEM1A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001020877.1

Ensembl

ENSRNOG00000066151, ENSRNOT00000099590, ENSRNOP00000091315

PRO

Q4V890

RGD

1561112