Reactome | Btbd6 [cytosol]

Btbd6 [cytosol]

Stable Identifier

R-RNO-8863208

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

BTBD6, F1M7U0

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Btbd6 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:F1M7U0

Gene Names

Btbd6

Reference Genes

BioGPS Gene:690367 Btbd6

ENSEMBL:ENSRNOG00000014693

ENSEMBL:ENSRNOG00000014693.6 Btbd6

KEGG Gene (Rattus norvegicus):690367 Btbd6

Monarch:690367 Btbd6

NCBI Gene:690367 Btbd6

UCSC:F1M7U0 Btbd6

Reference Transcript

RefSeq:NM_001077683.2 Btbd6

Other Identifiers

10887555

1374592_at

17819208

6224106

6250008

6511071

6547526

6650996

6707032

690367

A_44_P714565

A_64_P080144

A_64_P088372

GE13848

GO:0005515

PH_rn_0013245

rc_AI229789_at

Participates

as a member of

BTB proteins [cytosol] (Rattus norvegicus)

Inferred From

BTBD6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001071151.2

Ensembl

ENSRNOT00000019768, ENSRNOG00000014693, ENSRNOP00000019768

RGD

1597323

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