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About
What is Reactome ?
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EPN1 [cytosol]
Stable Identifier
R-RNO-8865826
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
O88339
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
BAR domain proteins recruit dynamin (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
UBQLN2:UIM-containing proteins [cytosol] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
UBQLNs bind UIM-containing adaptor proteins (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
UNQLNs:UIM proteins [cytosol] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Clathrin recruits PIK3C2A (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Dissociation of clathrin-associated proteins (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
EPS15,EPN1,EPN2 [cytosol] (Rattus norvegicus)
EPN1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O88339
Reference Genes
BioGPS Gene:117277
ENSEMBL:ENSRNOG00000015753
KEGG Gene (Rattus norvegicus):117277
Monarch:117277
NCBI Gene:117277
UCSC:O88339
Reference Transcript
RefSeq:NM_057136.1
Participant Of
hasComponent
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane]
hasMember
EPS15,EPN1,EPN2 [cytosol]
Other forms of this molecule
EPN1 [plasma membrane]
Inferred From
EPN1 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_476477.1
PRO
O88339
PDB
1EYH
,
1KY6
,
1EDU
,
1H0A
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18484 Ap2a2
8
AP2A2(1-939) [secretory granule membrane]
(R-RNO-6800412)
AP2A2(1-939) [endolysosome membrane]
(R-RNO-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-RNO-6800414)
Adaptor Protein 2 alpha 2 subunit [plasma membrane]
(R-RNO-182073)
AP2A2(1-939) [plasma membrane]
(R-RNO-177502)
AP2A2-3 [endocytic vesicle membrane]
(R-RNO-416635)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-RNO-5138448)
AP2A2(1-939) [cytosol]
(R-RNO-182155)
0.775
6
UniProt:P17427
7
AP2A2(1-939) [secretory granule membrane]
(R-MMU-6800412)
AP2A2(1-939) [endolysosome membrane]
(R-MMU-6784819)
AP2A2(1-939) [ficolin-1-rich granule membrane]
(R-MMU-6800414)
AP2A2(1-939) [plasma membrane]
(R-MMU-177502)
AP2A2-3 [endocytic vesicle membrane]
(R-MMU-416635)
AP2A2(1-939) [clathrin-coated endocytic vesicle membrane]
(R-MMU-5138448)
AP2A2(1-939) [cytosol]
(R-MMU-182155)
0.743
4
UniProt:Q06407
6
ARHGAP12 [cytosol]
(R-SCE-2976016-5)
ARHGAP15 [cytosol]
(R-SCE-195145-5)
ARHGAP9 [cytosol]
(R-SCE-2976572-5)
ARHGAP27 [cytosol]
(R-SCE-8873920-5)
ARHGAP9 [extracellular region]
(R-SCE-6806529-5)
ARHGAP9 [secretory granule lumen]
(R-SCE-6804973-5)
0.527
2
UniProt:P39083
6
ARHGAP12 [cytosol]
(R-SCE-2976016-3)
ARHGAP15 [cytosol]
(R-SCE-195145-3)
ARHGAP9 [cytosol]
(R-SCE-2976572-3)
ARHGAP27 [cytosol]
(R-SCE-8873920-3)
ARHGAP9 [extracellular region]
(R-SCE-6806529-3)
ARHGAP9 [secretory granule lumen]
(R-SCE-6804973-3)
0.527
2
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