Reactome | Tacr1 [clathrin-coated endocytic vesicle membrane]

Tacr1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869122

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

TACR1, P14600

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tacr1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P14600

Gene Names

Tacr1

Reference Genes

BioGPS Gene:24807 Tacr1

ENSEMBL:ENSRNOG00000005853

ENSEMBL:ENSRNOG00000005853.6 Tacr1

ENSEMBL:ENSRNOG00055012086

ENSEMBL:ENSRNOG00060002187

ENSEMBL:ENSRNOG00065016627

KEGG Gene (Rattus norvegicus):24807 Tacr1

Monarch:24807 Tacr1

NCBI Gene:24807 Tacr1

UCSC:P14600 Tacr1

Reference Transcript

RefSeq:NM_012667.2 Tacr1

Other Identifiers

10856525

1369199_at

1381181_at

1387474_at

17784668

24807

5758425

5778682

5836497

5977899

5989070

6090334

6234349

6303921

6514760

A_44_P215075

GE1145681

GE19889

GO:0003012

GO:0004930

GO:0004995

GO:0005886

GO:0005929

GO:0007018

GO:0007186

GO:0007204

GO:0007217

GO:0016020

GO:0016496

GO:0022414

GO:0023052

GO:0036126

GO:0043226

GO:0048265

GO:0048870

GO:0060089

GO:0061827

GO:0070472

GO:0071944

GO:0097225

GO:1902093

ILMN_1376350

M64236_at

PH_rn_0006577

Participates

as a candidate of

ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Tacr1 [plasma membrane]

Inferred From

TACR1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_036799.1

ZINC - Investigational

NK1R_RAT

ZINC - Metabolites

NK1R_RAT

ZINC - Substances

NK1R_RAT

ZINC - Biogenic

NK1R_RAT

Ensembl

ENSRNOT00000007984, ENSRNOP00000007984, ENSRNOG00000005853

ZINC target

P14600

PRO

P14600

RGD

3811

ZINC - Predictions - Purchasable

NK1R_RAT

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