Reactome | Tfrc [clathrin-coated endocytic vesicle membrane]

Tfrc [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869124

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

TFRC(1-760), Q99376

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of clathrin-associated proteins (Rattus norvegicus)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Tfrc [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q99376

Gene Names

Tfrc

Reference Genes

BioGPS Gene:64678 Tfrc

ENSEMBL:ENSRNOG00000001766

KEGG Gene (Rattus norvegicus):64678 Tfrc

Monarch:64678 Tfrc

NCBI Gene:64678 Tfrc

UCSC:Q99376 Tfrc

Reference Transcript

Participates

as a component of

TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Tfrc [Golgi membrane]

Tfrc [cytoplasmic vesicle membrane]

Tfrc [plasma membrane]

Tfrc [endosome membrane]

Inferred From

TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_006248524.1, NP_073203.1, XP_006248525.1

GlyGen

Q99376

RGD

70488

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.499	3

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