Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

Stable Identifier
R-RNO-9012709
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

Rat mitochondrial (Got2) (Cechetto et al. 2002) is a dimeric protein requiring pyridoxal phosphate for activity. Got2 mediates the reversible transamination between L-cysteine (L-Cys) and 2-oxoglutarate (2OG, aka alpha-ketoglutarate) to form 3-methylpyruvate (3MPYR) and glutamate (Glu) (Ubuka et al. 1978).

Literature References
PubMed ID Title Journal Year
754189 Purification and characterization of mitochondrial cysteine aminotransferase from rat liver

Ubuka, T, Umemura, S, Yuasa, S, Kinuta, M, Watanabe, K

Physiol. Chem. Phys. 1978
11962739 Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues

Cechetto, JD, Sadacharan, SK, Berk, PD, Gupta, RS

Histol. Histopathol. 2002
Participants
Catalyst Activity
Catalyst Activity
Title
L-cysteine:2-oxoglutarate aminotransferase activity of Got2 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created