Mecp2:Sin3a complex binds Gria2 gene promoter

Stable Identifier
R-RNO-9022364
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mecp2:Sin3a complex binds Gria2 gene promoter
In rat cortical neurons, neuronal activity induces binding of the Mecp2, in complex with Sin3a and Hdac1, to the promoter of the Gria2 (Glur2 gene), encoding glutamate receptor 2. Prior neuronal activity induced phosphorylation of Mecp2 at serine residue S421 may be involved (Qiu et al. 2012).
Literature References
PubMed ID Title Journal Year
22262897 The Rett syndrome protein MeCP2 regulates synaptic scaling

Ghosh, A, Qiu, Z, Zhang, Y, Liu, XY, Lieberman, DN, Sylwestrak, EL

J. Neurosci. 2012
Participants
Input
Output
Orthologous Events
MECP2:SIN3A complex binds GRIA2 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-10-02)
Reviewed
Krishnaraj, R  (2018-08-07)
Christodoulou, J  (2018-08-07)
Created
Orlic-Milacic, M  (2017-09-22)
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