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Shc1 bound to activated Ntrk2 recruits Grb2:Sos1
Stable Identifier
R-RNO-9030518
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Rat Shc1, recruited to activated rat Ntrk2 (TrkB), binds rat Grb2:Sos1 (Chan et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
21615729
Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death
Chen, WL
,
Li, FC
,
Hsu, KS
,
Chan, JY
,
Sun, EY
,
Chang, AY
,
Chan, SH
Br. J. Pharmacol.
2011
Participants
Input
Bdnf,Ntf4:p-5Y-Ntrk2 homodimer:p-Y314-Shc1 [plasma membrane]
(Rattus norvegicus)
Grb2:Sos1 [cytosol]
(Rattus norvegicus)
Output
Bdnf,Ntf4:p-5Y-Ntrk2:p-Y314-Shc1:Grb2:Sos1 [plasma membrane]
(Rattus norvegicus)
Orthologous Events
SHC1 bound to activated NTRK2 recruits GRB2:SOS1 (Homo sapiens)
Authored
Orlic-Milacic, M (2018-01-05)
Reviewed
Castrén, E (2018-02-13)
Antila, H (2018-02-13)
Created
Orlic-Milacic, M (2017-11-29)
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