Ntrk2 activates Ras signaling through Shc1

Stable Identifier
R-RNO-9030763
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
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 | PPTX  | SBGN
Ntrk2 activates Ras signaling through Shc1
In rat neurons, Shc1-mediated recruitment of the Grb2:Sos1 complex to the activated Ntrk2 (TrkB) receptor leads to activation of Ras (Chan et al. 2001).
Literature References
PubMed ID Title Journal Year
21615729 Amelioration of central cardiovascular regulatory dysfunction by tropomyocin receptor kinase B in a mevinphos intoxication model of brain stem death

Chen, WL, Li, FC, Hsu, KS, Chan, JY, Sun, EY, Chang, AY, Chan, SH

Br. J. Pharmacol. 2011
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of Bdnf,Ntf4:p-5Y-Ntrk2:p-Y314-Shc1:Grb2:Sos1 [plasma membrane]

Physical Entity
Bdnf,Ntf4:p-5Y-Ntrk2:p-Y314-Shc1:Grb2:Sos1 [plasma membrane] (Rattus norvegicus)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
NTRK2 activates RAS signaling through SHC1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-29)
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