Fyn-mediated phosphorylation of Grin2b

Stable Identifier
R-RNO-9032619
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Fyn-mediated phosphorylation of Grin2b
In rat brain and spinal cord, kinase activity of Fyn is needed for tyrosine phosphorylation of the Grin2b (NR2B) subunit of the NMDA receptor complex in response to Bdnf-mediated activation of the Ntrk2(TrkB) receptor (Mizuno et al. 2003, Li et al. 2017). The exact stoichiometry of this reaction and involvement of other proteins is not known.
Literature References
PubMed ID Title Journal Year
12663749 Involvement of BDNF receptor TrkB in spatial memory formation

Mizuno, M, Yamada, K, He, J, Nakajima, A, Nabeshima, T

Learn. Mem. 2003
28497343 BDNF Contributes to Spinal Long-Term Potentiation and Mechanical Hypersensitivity Via Fyn-Mediated Phosphorylation of NMDA Receptor GluN2B Subunit at Tyrosine 1472 in Rats Following Spinal Nerve Ligation

Li, S, Cai, J, Feng, ZB, Jin, ZR, Liu, BH, Zhao, HY, Jing, HB, Wei, TJ, Yang, GN, Liu, LY, Cui, YJ, Xing, GG

Neurochem. Res. 2017
Participants
Input
Output
Orthologous Events
FYN-mediated phosphorylation of GRIN2B (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Antila, H  (2018-02-13)
Castrén, E  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-15)
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